Scheliga Sebastian, Kellermann Thilo, Lampert Angelika, Rolke Roman, Spehr Marc, Habel Ute
Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany.
JARA-Institute Brain Structure Function Relationship, Pauwelsstraße 30, 52074 Aachen, Germany.
Rev Neurosci. 2022 Sep 12;34(2):223-245. doi: 10.1515/revneuro-2022-0065. Print 2023 Feb 23.
Previous fMRI research identified superior temporal sulcus as central integration area for audiovisual stimuli. However, less is known about a general multisensory integration network across senses. Therefore, we conducted activation likelihood estimation meta-analysis with multiple sensory modalities to identify a common brain network. We included 49 studies covering all Aristotelian senses i.e., auditory, visual, tactile, gustatory, and olfactory stimuli. Analysis revealed significant activation in bilateral superior temporal gyrus, middle temporal gyrus, thalamus, right insula, and left inferior frontal gyrus. We assume these regions to be part of a general multisensory integration network comprising different functional roles. Here, thalamus operate as first subcortical relay projecting sensory information to higher cortical integration centers in superior temporal gyrus/sulcus while conflict-processing brain regions as insula and inferior frontal gyrus facilitate integration of incongruent information. We additionally performed meta-analytic connectivity modelling and found each brain region showed co-activations within the identified multisensory integration network. Therefore, by including multiple sensory modalities in our meta-analysis the results may provide evidence for a common brain network that supports different functional roles for multisensory integration.
先前的功能磁共振成像研究将颞上沟确定为视听刺激的中央整合区域。然而，对于跨感官的一般多感官整合网络，人们了解得较少。因此，我们进行了多感官模态的激活可能性估计荟萃分析，以确定一个共同的脑网络。我们纳入了49项涵盖亚里士多德所有感官（即听觉、视觉、触觉、味觉和嗅觉刺激）的研究。分析显示双侧颞上回、颞中回、丘脑、右侧岛叶和左侧额下回有显著激活。我们认为这些区域是一个具有不同功能作用的一般多感官整合网络的一部分。在这里，丘脑作为第一个皮质下中继站，将感觉信息投射到颞上回/沟的高级皮质整合中心，而作为冲突处理脑区的岛叶和额下回则促进不一致信息的整合。我们还进行了荟萃分析连接建模，发现每个脑区在确定的多感官整合网络内都显示出共同激活。因此，通过在我们的荟萃分析中纳入多种感官模态，结果可能为一个支持多感官整合不同功能作用的共同脑网络提供证据。
