唾液生物标志物：帕金森病的非侵入性诊断方法
Salivary Biomarkers: Noninvasive Ways for Diagnosis of Parkinson's Disease.
作者信息
Salaramoli Sanaz, Joshaghani Hamid Reza, Hashemy Seyed Isaac
机构信息
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Neurol Res Int. 2023 Jul 3;2023:3555418. doi: 10.1155/2023/3555418. eCollection 2023.
Finding reliable biomarkers has a crucial role in Parkinson's disease (PD) assessments. Saliva is a bodily fluid, which might be used as a source of biomarkers for PD. Our article has reviewed several publications on salivary proteins in PD patients and their potential as biomarkers. We find out that -Syn's proportion in oligomeric form is higher in PD patients' saliva, which is potent to use as a biomarker for PD. The salivary concentration of DJ-1 and alpha-amylase is lower in PD patients. Also, substance P level is more moderate in PD patients. Although salivary flow rate is decreased in PD patients, high levels of heme oxygenase and acetylcholinesterase might be used as noninvasive biomarkers. Salivary miRNAs (miR-153, miR-223, miR-874, and miR-145-3p) are novel diagnostic biomarkers that should be given more attention.
寻找可靠的生物标志物在帕金森病（PD）评估中起着关键作用。唾液是一种体液，可能用作PD生物标志物的来源。我们的文章回顾了几篇关于PD患者唾液蛋白及其作为生物标志物潜力的出版物。我们发现，PD患者唾液中寡聚形式的α-突触核蛋白比例更高，这有可能用作PD的生物标志物。PD患者唾液中DJ-1和α-淀粉酶的浓度较低。此外，PD患者中P物质水平更为适中。虽然PD患者唾液流速降低，但高水平的血红素加氧酶和乙酰胆碱酯酶可能用作非侵入性生物标志物。唾液微小RNA（miR-153、miR-223、miR-874和miR-145-3p）是新型诊断生物标志物，应给予更多关注。
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