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疑似有症状的感染性原发性主动脉瘤经证实为源自不明原发灶转移性癌的主动脉肿瘤:一例报告并文献复习

Suspected Symptomatic Infected Native Aortic Aneurysm Turns Out To Be Aortic Tumour Originating From Metastatic Cancer of Unknown Primary: A Case Report and Review of Literature.

作者信息

Passos Laina, Zielasek Christian, Kotelis Drosos, Makaloski Vladimir, Bosiers Michel

机构信息

Department of Vascular Surgery, University Hospital Bern, University of Bern, Bern, Switzerland.

出版信息

EJVES Vasc Forum. 2024 Jul 4;62:21-24. doi: 10.1016/j.ejvsvf.2024.06.002. eCollection 2024.

Abstract

INTRODUCTION

The non-specific clinical presentation of a primary aortic tumour may mimic infectious processes. Together with its rarity, this resemblance can complicate timely identification and pose diagnostic challenges.

REPORT

The case of a 77 year old male patient complaining of abdominal pain radiating to the back, fatigue, and loss of appetite for a month, is presented. Contrast enhanced computed tomography showed a 47 mm infrarenal aortic aneurysm with peripheral enhancement. With suspicion of an infected native aortic aneurysm, open aortic repair was performed using a bovine pericardial Y prosthesis. The intra-operative biopsy revealed a malignant undifferentiated neoplasm, which later turned out to originate from metastatic cancer of unknown primary. The patient died six months later following comprehensive and extensive oncological treatment, which included radiotherapy and chemotherapy.

DISCUSSION

Given the scarcity of literature and challenges in classification, treatment recommendations rely on a multidisciplinary approach, involving surgery, radiotherapy, and chemotherapy. Despite the lack of established guidelines, early intervention, even in metastatic cases, may improve clinical outcomes. Surgical resection, whenever appropriate, is advocated, as it not only alleviates symptoms, but intra-operative histological sampling also aids in obtaining a definitive diagnosis.

摘要

引言

原发性主动脉肿瘤的非特异性临床表现可能类似感染性疾病。加之其罕见性,这种相似性会使及时识别变得复杂,并带来诊断挑战。

病例报告

本文介绍了一名77岁男性患者的病例,该患者主诉腹痛并放射至背部,伴有疲劳和食欲不振,症状持续一个月。增强计算机断层扫描显示肾下主动脉瘤,直径47毫米,周边有强化。因怀疑是感染性原发性主动脉瘤,遂使用牛心包Y形假体进行了开放性主动脉修复术。术中活检显示为恶性未分化肿瘤,后来证实是源自未知原发灶的转移性癌症。患者在接受包括放疗和化疗在内的全面、广泛的肿瘤治疗六个月后死亡。

讨论

鉴于文献资料稀缺以及分类方面的挑战,治疗建议依赖多学科方法,包括手术、放疗和化疗。尽管缺乏既定指南,但即使在转移性病例中,早期干预也可能改善临床结果。只要合适,就提倡手术切除,因为这不仅能缓解症状,术中组织学取样还有助于获得明确诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/648a/11415956/959617812e72/gr1.jpg

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