Fine A, Reynolds G P, Nakajima N, Jenner P, Marsden C D
Neurosci Lett. 1985 Jul 4;58(1):123-6. doi: 10.1016/0304-3940(85)90340-4.
A parkinsonian syndrome was induced in marmosets by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 4 days. Ten days following the onset of drug administration, brainstem and adrenal tissues were assayed for levels of monoamines and their metabolites. In the brainstem tegmentum, dopamine, its metabolites homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC), and noradrenaline were reduced, whereas 5-hydroxytryptamine (5-HT) levels were elevated, in comparison with untreated controls. In the adrenal gland, 5-HT and adrenaline levels were unchanged, but dopamine and noradrenaline were substantially elevated.
通过给予1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）4天，在狨猴中诱发了帕金森综合征。给药开始10天后，检测脑干和肾上腺组织中单胺及其代谢物的水平。与未处理的对照组相比，在脑干被盖中，多巴胺、其代谢物高香草酸（HVA）和二羟基苯乙酸（DOPAC）以及去甲肾上腺素减少，而5-羟色胺（5-HT）水平升高。在肾上腺中，5-HT和肾上腺素水平未改变，但多巴胺和去甲肾上腺素大幅升高。
