Jenner P, Rupniak N M, Rose S, Kelly E, Kilpatrick G, Lees A, Marsden C D
Neurosci Lett. 1984 Sep 7;50(1-3):85-90. doi: 10.1016/0304-3940(84)90467-1.
The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (1-4 mg/kg i.p.) for 4 days induced dose-dependent parkinsonism in the common marmoset within 48 h. MPTP produced profound akinesia, rigidity of the trunk and limbs, postural abnormalities, loss of vocalization and, in some cases, postural tremor. In a single animal the administration of L-DOPA in conjunction with a peripheral decarboxylase inhibitor, reversed the parkinsonian symptoms. Subsequent biochemical analysis showed a profound loss of dopamine and [3H]dopamine uptake in the caudate-putamen, but no change in specific [3H]spiperone binding.
腹腔注射1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）（1-4毫克/千克），连续4天，在48小时内可使普通狨猴产生剂量依赖性帕金森综合征。MPTP导致严重运动不能、躯干和四肢僵硬、姿势异常、发声丧失，在某些情况下还会出现姿势性震颤。在一只动物中，左旋多巴与外周脱羧酶抑制剂联合使用可逆转帕金森症状。随后的生化分析表明，尾状核-壳核中的多巴胺和[3H]多巴胺摄取量大幅减少，但特异性[3H]螺哌隆结合无变化。
