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超声引导下胎儿输血治疗严重恒河猴血型不合溶血病

Ultrasound-guided fetal blood transfusion for severe rhesus isoimmunization.

作者信息

de Crespigny L C, Robinson H P, Quinn M, Doyle L, Ross A, Cauchi M

出版信息

Obstet Gynecol. 1985 Oct;66(4):529-32.

PMID:3931012
Abstract

Four fetuses with severe rhesus isoimmunization were transfused with packed red blood cells directly into the umbilical vein. The outcome was successful in three. In one infant, this ultrasound-guided technique resulted in resolution of severe fetal hydrops at 27 weeks, allowing delivery of a healthy nonhydropic infant at 33 weeks, and in the other three infants in prolongation of the pregnancy. The last four transfusions were performed after fetal neuromuscular blockade with curare. The procedure would appear to be associated with a low risk of complication and to provide an excellent chance of a successful outcome of a fetus with severe rhesus isoimmunization even when fetal hydrops is present.

摘要

对4例患有严重恒河猴血型免疫的胎儿直接经脐静脉输注浓缩红细胞。3例取得成功。其中1例婴儿,这种超声引导技术使27周时严重胎儿水肿消退,得以在33周分娩出健康的非水肿婴儿,另外3例婴儿妊娠得以延长。最后4次输血是在使用箭毒进行胎儿神经肌肉阻滞之后进行的。该操作似乎并发症风险较低,即使存在胎儿水肿,也能为患有严重恒河猴血型免疫的胎儿提供成功结局的绝佳机会。

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1
Ultrasound-guided fetal blood transfusion for severe rhesus isoimmunization.超声引导下胎儿输血治疗严重恒河猴血型不合溶血病
Obstet Gynecol. 1985 Oct;66(4):529-32.
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Ultrasound-guided fetal intravascular transfusion in a case of severe rhesus isoimmunization.
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Fetal intravascular transfusion for hydropic disease due to rhesus isoimmunization.针对恒河猴血型同种免疫所致水肿病的胎儿血管内输血
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引用本文的文献

1
Changes in fetal acid base status during intravascular transfusion.血管内输血期间胎儿酸碱状态的变化。
Arch Dis Child. 1988 Jul;63(7 Spec No):710-4. doi: 10.1136/adc.63.7_spec_no.710.
2
Use of intravascular transfusion to treat hydrops fetalis in a moribund fetus.使用血管内输血治疗濒死胎儿的胎儿水肿。
CMAJ. 1988 May 1;138(9):827-30.
3
Fetal intracardiac transfusions in patients with severe rhesus isoimmunisation.严重恒河猴血型同种免疫患者的胎儿心脏内输血
Br Med J (Clin Res Ed). 1988 Mar 26;296(6626):885-6. doi: 10.1136/bmj.296.6626.885.
4
Consequences of fetomaternal haemorrhage after intrauterine transfusion.宫内输血后母胎输血的后果。
BMJ. 1988 Nov 26;297(6660):1379-81. doi: 10.1136/bmj.297.6660.1379.