Nicolini U, Santolaya J, Fisk N M, Hubinont C, Kochenour N K, Greco P, Rodeck C H
Royal Postgraduate Medical School, Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, London.
Arch Dis Child. 1988 Jul;63(7 Spec No):710-4. doi: 10.1136/adc.63.7_spec_no.710.
Umbilical venous pH, PCO2, PO2, and base excess was measured immediately before and after 72 intravascular transfusions in 34 fetuses with erythroblastosis fetalis. In 67 uncomplicated transfusions, infused adult blood led to a mean (95% confidence intervals) fall in pH (0.037, CI 0.029 to 0.044) and base excess (2.03, CI 1.61 to 2.45) and a mean rise in PCO2 (0.24 kPa, CI 0.13 to 0.35). These changes correlated significantly with the increase in fetal haemoglobin and packed cell volume. Five transfusions were associated with complications within six hours: intrauterine death in two, fetal-distress necessitating delivery in two, and preterm labour in one. Two had pre-existing acidosis, whereas two of the three with normal blood gas and acid base measurements before transfusion had acute changes that were outside the normal ranges that had been established in uncomplicated transfusions.
对34例患有胎儿成红细胞增多症的胎儿在72次血管内输血前后，立即测量脐静脉的pH值、二氧化碳分压（PCO₂）、氧分压（PO₂）和碱剩余。在67次无并发症的输血中，输注的成人血液导致pH值平均下降（95%置信区间）（0.037，置信区间为0.029至0.044）和碱剩余下降（2.03，置信区间为1.61至2.45），以及二氧化碳分压平均升高（0.24千帕，置信区间为0.13至0.35）。这些变化与胎儿血红蛋白和血细胞比容的增加显著相关。5次输血在6小时内出现并发症：2例宫内死亡，2例因胎儿窘迫需要分娩，1例早产。2例有先前存在的酸中毒，而在输血前血气和酸碱测量正常的3例中，有2例出现了超出无并发症输血所确定的正常范围的急性变化。
