Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Int J Med Sci. 2024 Sep 3;21(12):2334-2342. doi: 10.7150/ijms.97240. eCollection 2024.
Older adults in low- and middle-income countries (LMICs) often suffer from both sarcopenia and stress urinary incontinence (SUI), two conditions that can significantly impact their health. However, the relationship between these conditions has not been thoroughly explored. We conducted a cross-sectional study using data from older adults aged 50 years or older from the first wave of the Longitudinal Ageing Study in India (LASI). Participants with complete data on sarcopenia and SUI were included, excluding female participants who were still menstruating. Sarcopenia was defined as decreased grip strength and slow movement. SUI was assessed based on questionnaire responses about whether the participant had ever passed urine when sneezing, coughing, laughing, or lifting heavy objects. We analyzed the data using multiple logistic regression analysis, interaction tests, and stratified analysis. Our results showed that sarcopenia was positively correlated with SUI in male participants after adjusting for adequate confounding factors (odds ratio [OR] = 1.37, 95% confidence interval [CI] [1.20, 1.56], p < 0.001). This correlation remained stable after adjusting for additional confounding factors (OR = 1.27, 95% CI [1.11, 1.45], p < 0.001). In female participants, a stable correlation between sarcopenia and SUI was also observed after adjusting for appropriate confounding factors (OR = 1.11, 95% CI [1.01, 1.23], p = 0.037). According to the results of interaction tests and stratified analysis, the positive correlation between sarcopenia and SUI is notably stronger among men who abstain from alcohol and women who haven't undergone hysterectomy. Sarcopenia and SUI were positively correlated in older Indian adults, regardless of gender. Drinking and a history of hysterectomy may be important influencing factors for both male and female older adults. Further large-scale clinical trials are necessary to confirm this association.
在中低收入国家(LMICs),老年人常常同时患有肌肉减少症和压力性尿失禁(SUI),这两种疾病会严重影响他们的健康。然而,这两种疾病之间的关系尚未得到充分探讨。
我们使用来自印度首次纵向老龄化研究(LASI)的 50 岁及以上老年人的第一波数据进行了一项横断面研究。纳入了有完整肌肉减少症和 SUI 数据的参与者,排除了仍处于月经期的女性参与者。肌肉减少症的定义为握力下降和动作缓慢。SUI 根据参与者在打喷嚏、咳嗽、大笑或举重物时是否有过尿失禁的问卷回答进行评估。我们使用多因素逻辑回归分析、交互检验和分层分析对数据进行了分析。
我们的研究结果表明,在调整了充分的混杂因素后,男性参与者中肌肉减少症与 SUI 呈正相关(比值比[OR] = 1.37,95%置信区间[CI] [1.20,1.56],p < 0.001)。在调整了其他混杂因素后,这种相关性仍然稳定(OR = 1.27,95% CI [1.11,1.45],p < 0.001)。在女性参与者中,在调整了适当的混杂因素后,也观察到肌肉减少症和 SUI 之间存在稳定的相关性(OR = 1.11,95% CI [1.01,1.23],p = 0.037)。根据交互检验和分层分析的结果,在不饮酒的男性和未接受子宫切除术的女性中,肌肉减少症和 SUI 之间的正相关更为显著。
肌肉减少症和 SUI 在印度老年成年人中呈正相关,无论性别如何。饮酒和子宫切除术史可能是男性和女性老年成年人的重要影响因素。需要进一步的大规模临床试验来证实这种关联。