Saleem Shahan, Rehman Ayesha, Akbar Amna, Ali Amir Iqbal, Jadoon Sarosh Khan, Khattak Muhammad Iftikhar, Mehraj Adnan
Cosmetic, Reconstructive and Burn Surgery, Jinnah Burn and Reconstructive Surgery Center, Lahore, PAK.
Surgery, Divisional Headquarters Teaching Hospital, Mirpur, PAK.
Cureus. 2024 Aug 21;16(8):e67425. doi: 10.7759/cureus.67425. eCollection 2024 Aug.
Burn patients are generally prone to infection, which causes the patient's condition to be even worse. However, there is no study regarding the difference between the mortality rate of infected and non-infected patients. Therefore, the aim was to identify and compare the global mortality rate between infected and non-infected patients who were admitted to plastic surgery units. We searched PubMed, ScienceDirect, and Google Scholar and finally included five articles for this meta-analysis. We determined the odds ratio (OR) value by forest plot and assessed the study bias by a funnel plot. We also analyzed the quality and heterogeneity. The OR was determined as 0.43 (95%CI: 0.07-2.60), indicating a higher mortality rate in infected burn patients as compared to non-infected patients. The funnel plot showed no significant study bias. The quality of the studies was assessed high as well, and the heterogeneity was determined significant (I>75%). The sensitivity analysis with the fixed effect model reconfirmed our main outcome. However, as a study limitation, we could not specifically determine the impact of strain-specific infection on the mortality rate and could not find more relevant research regarding this issue. We conclude that the overall non-infected burn patient mortality rate is lower as compared to the infected burn patients; however, non-infected patients can be prone to death if the burn degree is higher, the respiratory organ is injured, or the treatment is poor or delayed.
烧伤患者通常容易感染，这会使患者的病情更加严重。然而，目前尚无关于感染患者与未感染患者死亡率差异的研究。因此，本研究旨在确定并比较整形外科收治的感染患者与未感染患者的全球死亡率。我们检索了PubMed、ScienceDirect和谷歌学术，最终纳入了五篇文章进行这项荟萃分析。我们通过森林图确定比值比（OR）值，并通过漏斗图评估研究偏倚。我们还分析了研究质量和异质性。结果确定OR为0.43（95%CI：0.07 - 2.60），表明感染烧伤患者的死亡率高于未感染患者。漏斗图显示无显著研究偏倚。研究质量评估也较高，异质性显著（I>75%）。固定效应模型的敏感性分析再次证实了我们的主要结果。然而，作为研究的局限性，我们无法具体确定菌株特异性感染对死亡率的影响，也未能找到更多关于此问题的相关研究。我们得出结论，总体而言，未感染烧伤患者的死亡率低于感染烧伤患者；然而，如果烧伤程度较高、呼吸器官受损、治疗不佳或延迟，未感染患者也可能容易死亡。
