脑利钠肽在急性心力衰竭及其与肾小球滤过率的关系：系统评价和荟萃分析。
Brain natriuretic peptide in acute heart failure and its association with glomerular filtration rate: A systematic review and meta-analysis.
机构信息
Registered Medical Practitioner, Azad Jammu & Kashmir Medical College, Muzaffarabad, Azad Jammu and Kashmir, Pakistan.
Pakistan Institute of Medical Sciences, Islamabad, Pakistan.
出版信息
Medicine (Baltimore). 2024 Feb 23;103(8):e36933. doi: 10.1097/MD.0000000000036933.
BACKGROUND
Acute heart failure (AHF) is one of the most common cardiovascular diseases. Early diagnosis and prognosis are essential, as they can eventually lead to a fatal condition. Recently, brain natriuretic peptide (BNP) has been recognized as one of the most popular biomarkers for AHF. Changes in glomerular filtration rate (GFR) are often observed in AHF.
METHODS
We searched PubMed, Google Scholar, and ScienceDirect between March and June 2023. Original case control studies written in English that assessed levels oh BNP in AHF were included. Systematic reviews, letters to editor, correspondence, comprehensive reviews, and duplicated studies were excluded. Funnel plots were constructed to assess publication bias.
RESULTS
A total of 9 studies were selected and we obtained the mean difference (MD) of BNP level to be 2.57 (95% CI: 1.35, 3.78), and GFR to be -15.52, (95% CI: -23.35, -7.70) in AHF patients. Sensitivity analyses supported the robustness of the outcome.
CONCLUSION
Results indicated that BNP was a promising prognostic biomarker of AHF, whereas GFR was found to be negatively correlated with AHF.
背景
急性心力衰竭（AHF）是最常见的心血管疾病之一。早期诊断和预后至关重要，因为它们最终可能导致致命状况。最近，脑钠肽（BNP）已被认为是 AHF 最受欢迎的生物标志物之一。在 AHF 中经常观察到肾小球滤过率（GFR）的变化。
方法
我们在 2023 年 3 月至 6 月期间在 PubMed、Google Scholar 和 ScienceDirect 上进行了搜索。纳入了评估 AHF 中 BNP 水平的英文原始病例对照研究。排除了系统评价、给编辑的信、通信、综合评价和重复研究。构建漏斗图以评估发表偏倚。
结果
共选择了 9 项研究，我们得到 BNP 水平的平均差异（MD）为 2.57（95%CI：1.35，3.78），而 GFR 为 -15.52（95%CI：-23.35，-7.70）在 AHF 患者中。敏感性分析支持结果的稳健性。
结论
结果表明 BNP 是 AHF 有前途的预后生物标志物，而 GFR 与 AHF 呈负相关。
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