人乳来源乳酸菌：对烧伤创面模型的抗菌和免疫调节活性。
Human breast milk isolated lactic acid bacteria: antimicrobial and immunomodulatory activity on the burn wound model.
机构信息
Università degli Studi del Molise Department of Medicina e Scienze della Salute "V. Tiberio", Campobasso, Italy.
Unità Operativa (UO) Laboratorio Analisi, Responsible Research Hospital, Campobasso, Italy.
出版信息
Front Cell Infect Microbiol. 2024 Sep 6;14:1428525. doi: 10.3389/fcimb.2024.1428525. eCollection 2024.
INTRODUCTION
Managing burn injuries is a challenge in healthcare. Due to the alarming increase in antibiotic resistance, new prophylactic and therapeutic strategies are being sought. This study aimed to evaluate the potential of live Lactic Acid Bacteria for managing burn infections, using as an alternative preclinical animal model and comparing the outcomes with a common antibiotic.
METHODS
The antimicrobial activity of LAB isolated from human breast milk was assessed against ATCC 27853. Additionally, the immunomodulatory effects of LAB were evaluated using the burn wound infection model.
RESULTS AND DISCUSSION
results demonstrated the antimicrobial activity of Lactic Acid Bacteria against . results show that their prophylactic treatment improves, statistically significant, larval survival and modulates the expression of immunity-related genes, Gallerimycin and Relish/NF-κB, strain-dependently. These findings lay the foundation and suggest a promising alternative for burn wound prevention and management, reducing the risk of antibiotic resistance, enhancing immune modulation, and validating the potential as a skin burn wound model.
简介
在医疗保健领域，烧伤的处理是一个挑战。由于抗生素耐药性的惊人增长，人们正在寻求新的预防和治疗策略。本研究旨在评估活乳酸菌在管理烧伤感染方面的潜力，使用 作为替代临床前动物模型，并将结果与一种常见抗生素进行比较。
方法
评估从人乳中分离出的 LAB 对 ATCC 27853 的抗菌活性。此外，还使用 烧伤感染模型评估了 LAB 的免疫调节作用。
结果与讨论
结果表明，乳酸菌对 具有抗菌活性。结果表明，它们的预防性治疗可显著提高幼虫的存活率，并在一定程度上调节与免疫相关的基因 Gallerimycin 和 Relish/NF-κB 的表达。这些发现为烧伤伤口的预防和管理奠定了基础，并为替代抗生素提供了有希望的方法，降低了抗生素耐药性的风险，增强了免疫调节，并验证了 作为皮肤烧伤模型的潜力。
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