Novel benzimidazole-based azine derivatives as potent urease inhibitors: synthesis, and approach.

In light of various biological activities of benzimidazole and azines, this study focuses on reporting novel derivatives of benzimidazole nucleus. Twenty novel azines of benzimidazole were synthesized, characterized and tested for urease inhibitory activity. All these derivatives showed excellent to good inhibition in the range of IC values 14.21 ± 1.87 to 76.11 ± 1.81 μM by comparing with standard thiourea 21.14 ± 0.42 μM. Docking studies were performed for the targeted benzimidazole derivatives to understand the binding mechanics. The results indicated higher binding efficacy compared with the reference inhibitor. This work identifies potential lead candidates for novel urease inhibitors, which with industrial support may be harnessed for the development of new drugs.