Lab in Biotechnology and Biosignal Transduction, Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India.
Neurosurg Rev. 2024 Sep 23;47(1):666. doi: 10.1007/s10143-024-02914-y.
The article "Differential DNA Methylation Associated with Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Systematic Review" by Tomasz Klepinowski et al. offers an in-depth analysis of the relationship between DNA methylation and delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH). By systematically reviewing databases like PubMed, MEDLINE, Scopus, and Web of Science, the authors identify key genes, including ITPR3, HAMP, INSR, and CDHR5, as potential biomarkers for early DCI diagnosis. Their meticulous adherence to PRISMA guidelines and the STROBE statement for quality assessment enhances the study's credibility. However, the review could be improved by discussing methodological variability, statistical power, and the functional relevance of identified CpG sites. Additional sections on mechanistic pathways, integration with other omics data, clinical translation, and ethical considerations would further strengthen the review, providing a more comprehensive understanding of epigenetic factors in DCI and paving the way for future therapeutic interventions.
文章“与颅内动脉瘤性蛛网膜下腔出血后迟发性脑缺血相关的差异 DNA 甲基化：系统综述”由 Tomasz Klepinowski 等人撰写，深入分析了 DNA 甲基化与颅内动脉瘤性蛛网膜下腔出血（aSAH）后迟发性脑缺血（DCI）之间的关系。通过系统地审查 PubMed、MEDLINE、Scopus 和 Web of Science 等数据库，作者确定了 ITPR3、HAMP、INSR 和 CDHR5 等关键基因，它们可能是早期 DCI 诊断的生物标志物。他们严格遵循 PRISMA 指南和 STROBE 声明进行质量评估，提高了研究的可信度。然而，通过讨论方法学变异性、统计能力以及鉴定的 CpG 位点的功能相关性，可以进一步改进该综述。增加关于机制途径、与其他组学数据的整合、临床转化和伦理考虑的部分，将进一步加强该综述，更全面地了解 DCI 中的表观遗传因素，并为未来的治疗干预铺平道路。
