Magnetic particle imaging (MPI) is a tracer-based medical imaging modality with great potential due to its high sensitivity, high spatiotemporal resolution, and ability to quantify the tracer concentration. Image reconstruction in MPI is an ill-posed problem, which the use of regularization methods can address. Multi-contrast MPI reconstructs the signal from different tracer materials or environments separately, resulting in multi-channel images that enable quantification of, for example, temperature or viscosity. Single- and multi-contrast MPI reconstructions produce different kinds of artifacts. The objective of this work is threefold: first, to present the concept of multi-contrast specific MPI channel leakage artifacts; second, to ascertain the source of these leakage artifacts; and third, to introduce a method for their reduction.A definition for leakage artifacts is established, and a quantification method is proposed. A comprehensive analysis is conducted to establish a connection between the properties of the multi-contrast MPI system matrix and the leakage artifacts. Moreover, a two-step measurement and reconstruction method is introduced to reduce channel leakage artifacts between multi-contrast MPI channels.The severity of these artifacts correlates with the system matrix shape and condition number and depends on the similarity of the corresponding frequency components. Using the proposed two-step method on both semi-simulated and measured data a significant leakage reduction and speed up the convergence of the multi-contrast MPI reconstruction was observed.The multi-contrast system matrix analysis we conducted is essential for understanding the source of the channel leakage artifacts and finding methods to reduce them. Our proposed two-step method is expected to improve the potential for real-time multi-contrast MPI applications.