Squires J E, Mintz P D, Clark S
Transfusion. 1985 Sep-Oct;25(5):410-3. doi: 10.1046/j.1537-2995.1985.25586020111.x.
A case of drug-associated immune hemolysis in a patient taking tolmetin for arthritic pain is described. Serologic tests showed that in the absence of tolmetin, the patient had a negative antibody screening test but a strongly positive direct antiglobulin test. An eluate prepared from the patient's red cells caused agglutination of all cells tested. However, addition of tolmetin revealed a high-titered tolmetin-dependent antibody in the patient's serum; the addition of tolmetin did not affect the results obtained with the eluate. within 3 months after the patient discontinued tolmetin, his hematocrit had increased to 45 percent, and his jaundice and bilirubinuria had disappeared. These results are similar to those described for zomepirac, another of the group of nonsteroidal anti-inflammatory medications.
本文描述了一名服用托美丁治疗关节炎疼痛的患者发生药物相关性免疫性溶血的病例。血清学检测显示，在未服用托美丁时，患者抗体筛查试验为阴性，但直接抗球蛋白试验呈强阳性。从患者红细胞制备的洗脱液使所有检测的细胞发生凝集。然而，加入托美丁后发现患者血清中有高滴度的托美丁依赖性抗体；加入托美丁并不影响洗脱液检测结果。患者停用托美丁后3个月内，血细胞比容升至45%，黄疸和胆红素尿消失。这些结果与非甾体抗炎药组中的另一种药物佐美酸所描述的结果相似。
