Sosler S D, Behzad O, Garratty G, Lee C L, Postoway N, Khomo O
Am J Clin Pathol. 1985 Sep;84(3):391-4. doi: 10.1093/ajcp/84.3.391.
Upon hospital admission a patient was found to have severe anemia and a strongly positive direct antiglobulin test (DAT). The patient was taking probenecid periodically for gout. An antibody was detected in the patient's serum that only reacted with red blood cells (RBCs) when probenecid was added. Eluates from the patient's RBCs, with and without the presence of drug, were nonreactive. Upon the discontinuation of probenecid, the patient's hemoglobin level improved steadily. We believe this to be the first reported case of immune hemolytic anemia associated with probenecid.
患者入院时被发现患有严重贫血，直接抗球蛋白试验（DAT）呈强阳性。该患者定期服用丙磺舒治疗痛风。在患者血清中检测到一种抗体，只有在加入丙磺舒时才与红细胞（RBC）发生反应。患者红细胞的洗脱液，无论有无药物存在，均无反应。停用丙磺舒后，患者血红蛋白水平稳步改善。我们认为这是首例报道的与丙磺舒相关的免疫性溶血性贫血病例。
