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基于人工智能后处理的糖尿病合并冠心病患者冠状动脉病变血流储备分数的研究

Exploration of fractional flow reservation score based on artificial intelligence post-processing for coronary artery lesions in patients with diabetes and coronary heart disease.

作者信息

Li Mei, Zhang Likun, Wang Yingcui, Xu Xiaohong

机构信息

Department of Cardiology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266035, Shandong, PR China.

Endocrinology Department, Qingdao Municipal Hospital (Group), Qingdao Geriatric Hospital, Qingdao 266000, Shandong, PR China.

出版信息

SLAS Technol. 2024 Dec;29(6):100196. doi: 10.1016/j.slast.2024.100196. Epub 2024 Sep 21.

DOI:10.1016/j.slast.2024.100196
PMID:39313159
Abstract

In order to evaluate the relationship between coronary heart disease (CHD) and fractional flow reservation (FFR) in patients with different levels of CHD and diabetes, this paper used AI (artificial intelligence) post-processing technology to detect CHD and FFR. In this paper, 94 patients suspected of CHD who underwent coronary arteriography (CAG) in a hospital between December 2022 and February 2023 were examined by coronary computed tomography angiography (CCTA) and FFR. Based on CCTA, AI software is used to process CCTA images, diagnose coronary plaques, coronary stenosis, corresponding stenosis of different types of plaques, and FFR values. The diagnostic performance of AI was evaluated using expert diagnosis, CAG diagnosis, and FFR examination results as the "gold standard". According to the diagnosis results, the relationship between FFR and CHD patients with diabetes at different levels was studied. The research results showed that AI image diagnosis has high sensitivity, specificity, and accuracy, and has good diagnostic effects on coronary plaques, coronary stenosis, stenosis corresponding to different types of plaques, and FFR values. The fasting blood glucose levels and FFR values of three groups of CHD patients were statistically significant, and correlation analysis revealed a negative correlation between the two. Using AI for CCTA diagnosis can efficiently, conveniently, and accurately obtain the required data, improving clinical diagnostic efficiency and accuracy. The analysis of AI recognition results found that in patients with CHD, the FFR value of patients with diabetes decreased, and the FFR value was negatively correlated with the fasting blood glucose concentration, indicating that CHD patients may lead to myocardial ischemia in the blood supply area due to the decline of their coronary blood flow reserve.

摘要

为了评估不同程度冠心病(CHD)合并糖尿病患者中冠心病与血流储备分数(FFR)之间的关系,本文采用人工智能(AI)后处理技术检测冠心病和FFR。本文对2022年12月至2023年2月期间在某医院接受冠状动脉造影(CAG)的94例疑似冠心病患者进行了冠状动脉计算机断层扫描血管造影(CCTA)和FFR检查。基于CCTA,使用AI软件处理CCTA图像,诊断冠状动脉斑块、冠状动脉狭窄、不同类型斑块对应的狭窄情况以及FFR值。以专家诊断、CAG诊断和FFR检查结果作为“金标准”评估AI的诊断性能。根据诊断结果,研究不同程度FFR与合并糖尿病的冠心病患者之间的关系。研究结果表明,AI图像诊断具有较高的敏感性、特异性和准确性,对冠状动脉斑块、冠状动脉狭窄、不同类型斑块对应的狭窄情况以及FFR值均有良好的诊断效果。三组冠心病患者的空腹血糖水平和FFR值差异具有统计学意义,相关性分析显示两者呈负相关。使用AI进行CCTA诊断能够高效、便捷且准确地获取所需数据,提高临床诊断效率和准确性。对AI识别结果的分析发现,在冠心病患者中,糖尿病患者的FFR值降低,且FFR值与空腹血糖浓度呈负相关,提示冠心病患者可能由于冠状动脉血流储备下降导致供血区域心肌缺血。

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引用本文的文献

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Efficacy of artificial intelligence-based FFR technology for coronary CTA stenosis detection in clinical management of coronary artery disease: a systematic review.基于人工智能的血流储备分数技术在冠心病临床管理中检测冠状动脉CTA狭窄的疗效:一项系统评价
Front Physiol. 2025 Jul 31;16:1635923. doi: 10.3389/fphys.2025.1635923. eCollection 2025.