Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef, Egypt.
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
Planta Med. 2024 Nov;90(14):1059-1079. doi: 10.1055/a-2412-8471. Epub 2024 Sep 23.
has been employed traditionally to treat various ailments including as add-on therapy for cancer treatment. formulations have been employed as adjuvants in cancer treatment due to their immunomodulatory activities as well as to alleviate the side effects of conventional cancer therapies. The present review provides updated information from the past 10 years on the immunomodulatory activity and inhibitory effects of on cancer cells, its safety profile, and recent nanotechnology development. extracts and their bioactive phytochemicals, particularly lectins, viscotoxins, and polyphenols, have demonstrated immunomodulatory activity and inhibitory effects against various types of cancer, with low cytotoxicity and side effects, in experimental studies and demonstrated promising anticancer activity in clinical studies in cancer patients. extracts have been shown to enhance immune function by promoting cytokine secretion and inducing both innate and adaptive immune responses, which can help improve immune surveillance against cancer cells. The development of nanoparticles has boosted their biological activities, including inhibitory activity on cancer cells, and could possibly reduce undesired side effects of the plant. Further prospective studies on the plant as a source of new medicinal agents for use as an adjuvant in the treatment of cancer must be performed to provide sufficient efficacy and safety data.
在传统医学中，已被用于治疗各种疾病，包括作为癌症治疗的辅助疗法。由于其免疫调节活性以及减轻常规癌症疗法的副作用，各种制剂已被用作癌症治疗的佐剂。本综述提供了过去 10 年关于 对癌细胞的免疫调节活性和抑制作用、其安全性概况以及最近纳米技术发展的最新信息。 的提取物及其生物活性植物化学成分，特别是凝集素、粘毒素和多酚，已在实验研究中显示出对各种类型癌症的免疫调节活性和抑制作用，且具有低细胞毒性和副作用，并在癌症患者的临床研究中显示出有希望的抗癌活性。 的提取物已被证明通过促进细胞因子分泌和诱导先天和适应性免疫反应来增强免疫功能，这有助于改善对癌细胞的免疫监视。 的纳米粒子的开发提高了它们的生物活性，包括对癌细胞的抑制活性，并且可能减少植物的不良副作用。必须对该植物作为新型药物来源进行进一步的前瞻性研究，以作为癌症治疗的辅助剂提供足够的疗效和安全性数据。
