Research Institute, Green Vet, Yongin-si, Korea.
Department of Veterinary Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Korea.
Vet Clin Pathol. 2024 Sep;53(3):369-373. doi: 10.1111/vcp.13361. Epub 2024 Jun 21.
A feline cutaneous melanocytic tumor in a 1-year-old cat is reported. The cytologic, histologic, and immunohistochemical characteristics of the pediatric feline cutaneous melanocytoma are included. A solitary, black-colored nodule on the head was histologically diagnosed as the epithelioid type of melanocytoma. Immunohistochemically, the neoplastic melanocytes demonstrated immunoreactivity to the S100 and MelanA antibodies but not to the PNL2 antibody. Despite high mitotic counts (17/10HPFs) and a Ki67 index (33%) suggesting malignant melanoma, the patient exhibited a favorable 5-month outcome. The mitotic activity of the neoplastic cells may not provide a reliable prediction for feline melanocytic tumors.
现报道一例发生于 1 岁猫的皮肤黑素细胞瘤。本文包括儿科猫皮肤黑素细胞瘤的细胞学、组织学和免疫组织化学特征。头部单发黑色结节组织学诊断为上皮样型黑素细胞瘤。免疫组织化学染色显示，肿瘤性黑素细胞对 S100 和 MelanA 抗体呈阳性反应，但对 PNL2 抗体呈阴性反应。尽管有提示恶性黑色素瘤的高有丝分裂计数（17/10HPFs）和 Ki67 指数（33%），但患者表现出良好的 5 个月预后。肿瘤细胞的有丝分裂活性可能不能为猫的黑素细胞瘤提供可靠的预测。
