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血清阴性重症肌无力:一种由SARS-CoV-2引发的罕见疾病还是一种巧合?

Seronegative Myasthenia Gravis: A Rare Disease Triggered by SARS-CoV-2 or a Coincidence?

作者信息

Castro Silva Beatriz, Saianda Duarte Miguel, Rodrigues Alves Nuno, Vicente Patricia, Araújo José

机构信息

Internal Medicine, Hospital Beatriz Ângelo, Loures, PRT.

Neurology, Hospital Beatriz Ângelo, Loures, PRT.

出版信息

Cureus. 2024 Aug 22;16(8):e67511. doi: 10.7759/cureus.67511. eCollection 2024 Aug.

Abstract

Myasthenia gravis (MG) results from the production of autoantibodies against the neuromuscular junction, leading to muscle weakness. Although the exact cause is not fully understood, it is known that the onset and exacerbations of MG can occur after viral infections. We present the case of a patient with no prior history of MG with new-onset proximal muscle weakness and ptosis, following SARS-CoV-2 infection, This case underscores the potential for autoimmune diseases to be triggered by SARS-CoV-2.

摘要

重症肌无力(MG)是由针对神经肌肉接头产生自身抗体所致,会导致肌肉无力。尽管确切病因尚未完全明确,但已知重症肌无力的发病和病情加重可发生在病毒感染之后。我们报告了1例既往无重症肌无力病史的患者,在感染新型冠状病毒后出现新发近端肌无力和上睑下垂的病例。该病例强调了新型冠状病毒引发自身免疫性疾病的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e46c/11417286/b92a4f244796/cureus-0016-00000067511-i01.jpg

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