Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of Laboratory Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Front Immunol. 2024 Sep 9;15:1430179. doi: 10.3389/fimmu.2024.1430179. eCollection 2024.
Adult-onset immunodeficiency (AOID) mediated by anti-interferon-γ autoantibodies (AIGA) is a rare condition, particularly prevalent in Southeast Asia and southern China. We present a case study of a 62-year-old female with AOID who developed a severe pulmonary infection caused by (TM), leading to acute respiratory failure, generalized rash, multiple lymphadenopathies, bone destruction, and a mediastinal mass. Treatment included mechanical ventilation, antifungal medication, and corticosteroids, resulting in complete recovery and discharge. This case underscores the challenges of managing complex infections in AOID patients and highlights the importance of early diagnosis through metagenomic next-generation sequencing (mNGS) and appropriate intervention to improve clinical outcomes.
成人起病免疫缺陷（AOID）由抗干扰素-γ 自身抗体（AIGA）介导，是一种罕见疾病，尤其在东南亚和中国南方流行。我们报告了一例 62 岁女性 AOID 病例，她因感染（TM）而发生严重肺部感染，导致急性呼吸衰竭、全身性皮疹、多处淋巴结病、骨破坏和纵隔肿块。治疗包括机械通气、抗真菌药物和皮质类固醇，患者完全康复并出院。该病例强调了管理 AOID 患者复杂感染的挑战，并突出了通过宏基因组下一代测序（mNGS）早期诊断和适当干预以改善临床结局的重要性。
