Konak Hatice Ecem, Atalar Ebru, Hezer Habibe, Koçak Ulucaköy Rezan, Kayacan Erdoğan Esra, Babaoğlu Hakan, Armağan Berkan, Orhan Kevser, Doğan İsmail, Maraş Yüksel, Omma Ahmet, Karalezli Ayşegül, Erten Şükran, Küçükşahin Orhan, Güven Serdar Can
Ankara City Hospital.
Yıldırım Beyazıt University Medical School.
Sarcoidosis Vasc Diffuse Lung Dis. 2024 Sep 24;41(3):e2024035. doi: 10.36141/svdld.v41i3.15548.
The aim of this study is to investigate the characteristics of Primary Sjögren's syndrome (pSS)- interstitial lung disease (ILD) patients and compare them to those of pSS patients without ILD in the tertiary pSS-ILD cohort to evaluate potential risk factors for ILD occurrence and disease progression.
Patients followed up who met the 2016 American College of Rheumatology-European League Against Rheumatism classification criteria for pSS were retrospectively analyzed. The patients were grouped as those with ILD and those without ILD according to medical records. High-resolution computed tomography (HRCT)/ thorax CT (TCT) results of all ILD patients were evaluated. Data on demographics, comorbidities, clinical characteristics and laboratory findings were collected.
A total of 378 pSS patients, including 60 with ILD and 318 without ILD were detected to have at least one obtainable HRCT/TCT and were included in the study. In the cohort of pSS patients with at least one HRCT or TCT, the frequency of ILD was 15.8%. In the ILD group, the most common HRCT pattern was NSIP, and the most common findings were ground glass opacities, traction bronchiectasis, and honeycombing. Logistic regression analysis showed that male gender (OR:2.90), being diagnosed with pSS over the age of 50(OR:4,24), smoking history (OR:2.38), elevated LDH(OR:3.27), elevated ESR(OR:2.51) and lymphopenia (OR:5.12) were related with development of ILD while being diagnosed with ILD after the age of 60 (OR:8.5) was related with radiographic progression.
The study results provided a large spectrum view for pSS-ILD and pointed out several risk factors for ILD occurrence and radiographic progression.
本研究旨在调查原发性干燥综合征（pSS）-间质性肺疾病（ILD）患者的特征，并将其与三级pSS-ILD队列中无ILD的pSS患者进行比较，以评估ILD发生和疾病进展的潜在危险因素。
对符合2016年美国风湿病学会-欧洲抗风湿病联盟pSS分类标准的随访患者进行回顾性分析。根据病历将患者分为有ILD组和无ILD组。对所有ILD患者的高分辨率计算机断层扫描（HRCT）/胸部CT（TCT）结果进行评估。收集人口统计学、合并症、临床特征和实验室检查结果的数据。
共检测到378例pSS患者，其中60例有ILD，318例无ILD，至少有一次可获得的HRCT/TCT结果，并纳入研究。在至少有一次HRCT或TCT的pSS患者队列中，ILD的发生率为15.8%。在ILD组中，最常见的HRCT模式是NSIP，最常见的表现是磨玻璃影、牵拉性支气管扩张和蜂窝状改变。逻辑回归分析显示，男性（比值比：2.90）、50岁以上诊断为pSS（比值比：4.24）、吸烟史（比值比：2.38）、乳酸脱氢酶升高（比值比：3.27）、红细胞沉降率升高（比值比：2.51）和淋巴细胞减少（比值比：5.12）与ILD的发生有关，而60岁后诊断为ILD（比值比：8.5）与影像学进展有关。
研究结果为pSS-ILD提供了一个广泛的视角，并指出了ILD发生和影像学进展的几个危险因素。
