Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, China.
Int J Rheum Dis. 2020 Aug;23(8):1009-1018. doi: 10.1111/1756-185X.13881. Epub 2020 Jun 26.
To systematically review the prevalence and risk factors for interstitial lung disease (ILD) in patients with primary Sjögren's syndrome (pSS).
We searched PubMed, Embase, and Cochrane Library from inception to December 2019. Two investigators reviewed records according to predefined criteria. We calculated the pooled prevalence, weighted mean differences (WMDs), odds ratio (OR) and 95% confidence intervals (CIs) using a random effects model, and performed subgroup analysis, sensitivity analysis, and Egger's test.
In 23 studies with 6157 pSS patients, the pooled prevalence of ILD in pSS patients was 13% (95% CI: 9-19). The pSS-ILD prevalence was higher in Asia (20%) than that in Europe (10%). Male gender (OR = 1.92, 95% CI: 1.26-2.95), elder age (WMD = 9.25 years, 95% CI: 2.78-15.72) and higher C-reactive protein (CRP) (WMD = 3.92 mg/L, 95% CI: 0.27-1.61) was associated with ILD in pSS patients.
Interstitial lung disease was prevalent in pSS patients. Elder age, male gender and higher CRP were risk factors for pSS-ILD. Our data highlighted the importance of screening for ILD in high-risk pSS patients.
系统评价原发性干燥综合征（pSS）患者间质性肺疾病（ILD）的患病率和危险因素。
我们检索了 PubMed、Embase 和 Cochrane Library 从建库到 2019 年 12 月的文献。两名研究者根据预先设定的标准筛选文献。我们采用随机效应模型计算汇总患病率、加权均数差（WMD）、比值比（OR）和 95%置信区间（CI），并进行亚组分析、敏感性分析和 Egger 检验。
在纳入的 23 项研究中，共纳入 6157 例 pSS 患者，pSS 患者中 ILD 的总患病率为 13%（95%CI：9-19）。亚洲（20%）pSS-ILD 患病率高于欧洲（10%）。男性（OR=1.92，95%CI：1.26-2.95）、高龄（WMD=9.25 岁，95%CI：2.78-15.72）和高 C 反应蛋白（CRP）（WMD=3.92mg/L，95%CI：0.27-1.61）与 pSS 患者 ILD 相关。
ILD 在 pSS 患者中较为常见。高龄、男性和高 CRP 是 pSS-ILD 的危险因素。我们的数据强调了对高危 pSS 患者进行 ILD 筛查的重要性。
