Caraiola Simona, Voicu Laura, Opriș-Belinski Daniela, Cobilinschi Claudia Oana, Pârvu Magda Ileana, Ion Ion Andrei, Gologanu Daniela Ștefana, Ionescu Răzvan Adrian
Fifth Department-Internal Medicine (Cardiology, Gastroenterology, Hepatology, Rheumatology, Geriatrics), Family Medicine, Occupational Medicine, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Internal Medicine Department, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Int J Mol Sci. 2025 Jun 19;26(12):5867. doi: 10.3390/ijms26125867.
Lung involvement is the most common extraglandular manifestation of primary Sjögren's Disease (pSjD). There is an increasing interest in finding the clinical/serological risk predictors of this feature. A cross-sectional study evaluating anti-SSA/Ro antibodies, anti-SSB/La antibodies, rheumatoid factor, antinuclear antibodies, and the diffusing capacity of the lungs for carbon monoxide (DLCO) in 26 pSjD patients who presented interstitial changes on the chest CT scan was performed. The titres and positivity rates for anti-SSA/Ro ( = 0.02, = 0.02) and anti-SSB/La antibodies ( = 0.01, = 0.001) proved to be significantly increased in patients with abnormal DLCO. Anti-SSB/La antibodies' titres seemed to be the best predictor for decreased DLCO-AUC 0.791 (0.587-0.994), = 0.016. A close-to-significance decrease was found in the titres ( = 0.07) and positivity rates- = 0.09 and OR of 0.15 (0.01-1.63)-of anti-SSB/La antibodies in patients with usual interstitial pneumonia (UIP), indicating their possible protective role against UIP. The lymphocytic interstitial pneumonitis (LIP) pattern on lung CT scan was significantly associated with the simultaneous positivity of the four examined serological markers ( = 0.03). The increase in anti-SSB/La antibody positivity rate in patients with LIP patterns was situated close to the significance level ( = 0.09). Quadruple positivity, as well as isolated anti-SSB/La positivity, could be risk factors for developing LIP in pSjD patients. Thus, anti-SSB/La antibodies might represent a marker of lung involvement in pSjD patients.
肺部受累是原发性干燥综合征（pSjD）最常见的腺外表现。人们对寻找这一特征的临床/血清学风险预测指标的兴趣与日俱增。对26例胸部CT扫描显示有间质性改变的pSjD患者进行了一项横断面研究，评估抗SSA/Ro抗体、抗SSB/La抗体、类风湿因子、抗核抗体以及肺一氧化碳弥散量（DLCO）。结果显示，DLCO异常的患者中，抗SSA/Ro（P = 0.02，OR = 0.02）和抗SSB/La抗体（P = 0.01，OR = 0.001）的滴度和阳性率显著升高。抗SSB/La抗体滴度似乎是DLCO降低的最佳预测指标——AUC为0.791（0.587 - 0.994），P = 0.016。在寻常型间质性肺炎（UIP）患者中，抗SSB/La抗体的滴度（P = 0.07）和阳性率（P = 0.09，OR为0.15（0.01 - 1.63））有接近显著的下降，表明它们可能对UIP有保护作用。肺部CT扫描显示的淋巴细胞间质性肺炎（LIP）模式与所检测的四种血清学标志物同时呈阳性显著相关（P = 0.03）。LIP模式患者中抗SSB/La抗体阳性率的升高接近显著水平（P = 0.09）。四重阳性以及单独的抗SSB/La阳性可能是pSjD患者发生LIP的危险因素。因此，抗SSB/La抗体可能是pSjD患者肺部受累的一个标志物。
