Mathur S N, Field F J, Spector A A, Armstrong M L
Biochim Biophys Acta. 1985 Oct 23;837(1):13-9. doi: 10.1016/0005-2760(85)90080-3.
The metabolism of arachidonic acid by cholesterol-enriched resident mouse peritoneal macrophages was investigated. The amounts of monohydroxyeicosatetraenoic acid (mono-HETE) produced by the cholesterol-rich macrophages were 2.5-fold greater when compared to control macrophages. The major lipoxygenase product, identified by high-performance liquid chromatography in both macrophages was 12-HETE. Since macrophages are important participants in the formation of atheromatous lesions, the increased metabolism of arachidonic acid to HETE products by cholesterol-rich macrophages could contribute to the initiation and progression of the atherosclerotic process.
研究了富含胆固醇的驻留小鼠腹膜巨噬细胞中花生四烯酸的代谢。与对照巨噬细胞相比，富含胆固醇的巨噬细胞产生的单羟基二十碳四烯酸（mono-HETE）量增加了2.5倍。通过高效液相色谱法在两种巨噬细胞中鉴定出的主要脂氧合酶产物均为12-HETE。由于巨噬细胞是动脉粥样硬化病变形成的重要参与者，富含胆固醇的巨噬细胞将花生四烯酸代谢为HETE产物的增加可能有助于动脉粥样硬化进程的启动和发展。
