Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui 230009, China.
Anhui Key Laboratory of Modern Biomanufacturing, School of Life Sciences, Anhui University, Hefei 230601, China.
Biomater Adv. 2025 Jan;166:214048. doi: 10.1016/j.bioadv.2024.214048. Epub 2024 Sep 19.
Designing bio-based polyurethane materials with excellent mechanical, biocompatibility, and self-healing properties simultaneously is currently a significant challenge due to the increasing demands for high-performance materials. In this study, we propose an asymmetric backbone strategy utilizing bio-based polycarbonate as the soft segment, equimolar ratios of lysine diisocyanate and isophorone diisocyanate as asymmetric hard segments, and isophorone diamine as the chain extender. The resulting polyurethane elastomers exhibit excellent mechanical properties, including high tensile stress (46.1 MPa), toughness (213.9 MJ/m), and fracture energy (98.47 kJ/m). The polyurethane elastomers demonstrate good self-healing and recyclable properties under simple heat treatment. Furthermore, biological experiments confirm the degradability and bio-safety of the bio-based polyurethane elastomers, which have shown potential in accelerating wound healing in mice when used as surgical sutures. These findings highlight the promising prospects of the obtained polyurethane elastomers in various applications, including biomedicine, flexible sensing, and electronic components.
设计具有优异机械性能、生物相容性和自修复性能的生物基聚氨酯材料目前是一个重大挑战，因为对高性能材料的需求不断增加。在本研究中，我们提出了一种不对称骨架策略，利用生物基聚碳酸酯作为软段，等摩尔比的赖氨酸二异氰酸酯和异佛尔酮二异氰酸酯作为不对称硬段，异佛尔酮二胺作为扩链剂。得到的聚氨酯弹性体具有优异的机械性能，包括高拉伸应力（46.1 MPa）、韧性（213.9 MJ/m）和断裂能（98.47 kJ/m）。聚氨酯弹性体在简单热处理下表现出良好的自修复和可回收性能。此外，生物实验证实了生物基聚氨酯弹性体的可降解性和生物安全性，当用作手术缝线时，它们已显示出在加速小鼠伤口愈合方面的潜力。这些发现突显了所获得的聚氨酯弹性体在生物医学、柔性传感和电子元件等各种应用中的广阔前景。
