Department of Clinical Pharmacology, Evidence-Based Therapeutics Group, Faculty of Medicine, Universidad de La Sabana and Clínica Universidad de La Sabana, Chía, Cundinamarca, Colombia.
Doctoral Programme of Biosciences, Universidad de La Sabana, Chía, Colombia.
Expert Opin Ther Targets. 2024 Sep;28(9):739-755. doi: 10.1080/14728222.2024.2407824. Epub 2024 Sep 24.
This review highlights the critical role of the endocannabinoid system (ECS) in regulating neuropathic pain and explores the therapeutic potential of cannabinoids. Understanding the mechanisms of the ECS, including its receptors, endogenous ligands, and enzymatic routes, can lead to innovative treatments for chronic pain, offering more effective therapies for neuropathic conditions. This review bridges the gap between preclinical studies and clinical applications by emphasizing ECS modulation for better pain management outcomes.
A review mapped the existing literature on neuropathic pain and the effects of modulating the ECS using natural and synthetic cannabinoids. This analysis examined ECS components and their alterations in neuropathic pain, highlighting the peripheral, spinal, and supraspinal mechanisms. This review aimed to provide a thorough understanding of the therapeutic potential of cannabinoids in the management of neuropathic pain.
Advances in cannabinoid research have shown significant potential for the management of chronic neuropathic pain. The study emphasizes the need for high-quality clinical trials and collaborative efforts among researchers, clinicians, and regulatory bodies to ensure safe and effective integration of cannabinoids into pain management protocols. Understanding the mechanisms and optimizing cannabinoid formulations and delivery methods are crucial for enhancing therapeutic outcomes.
本综述强调了内源性大麻素系统 (ECS) 在调节神经性疼痛中的关键作用，并探讨了大麻素的治疗潜力。 了解 ECS 的机制，包括其受体、内源性配体和酶途径，可以为慢性疼痛的创新治疗提供更多有效的神经性疾病治疗方法。 本综述通过强调 ECS 调节以实现更好的疼痛管理结果，弥合了临床前研究和临床应用之间的差距。
本综述对神经性疼痛和使用天然和合成大麻素调节 ECS 的现有文献进行了综述。 该分析检查了 ECS 成分及其在神经性疼痛中的改变，强调了外周、脊髓和中枢神经系统机制。 本综述旨在深入了解大麻素在神经性疼痛管理中的治疗潜力。
大麻素研究的进展表明，它们在管理慢性神经性疼痛方面具有很大的潜力。 该研究强调了需要进行高质量的临床试验，并需要研究人员、临床医生和监管机构之间开展合作，以确保安全有效地将大麻素纳入疼痛管理方案。 了解机制和优化大麻素配方和给药方法对于提高治疗效果至关重要。
