Herron Christopher, Iacono Karen, Nykanen David
Department of Pediatric Cardiology, Arnold Palmer Hospital for Children, Orlando, FL, USA.
Division of Pediatric Cardiology, Arnold Palmer Hospital for Children, 92 W Miller St, Orlando, FL, 34786, USA.
Pediatr Cardiol. 2025 Aug;46(6):1750-1753. doi: 10.1007/s00246-024-03656-w. Epub 2024 Sep 24.
ASD and PFO device-related thrombus is an uncommon phenomenon that can be seen both early- and late-post-closure. Typical risk factors include atrial fibrillation, hypercoagulable diseases/states, and lack of device endothelialization. We present an interesting case of a 15-year-old female who underwent PFO device closure after a renal infarction and was found to have biatrial device thrombus 3-month post-closure. She initially was managed with anticoagulation and antiplatelet therapy with intermittent systemic tPA but subsequently developed a new left atrial thrombus after complete resolution. Her device was surgically removed and found to be fully endothelialized. Her case highlights the lack of current guidelines for ASD/PFO device-related thrombus.
房间隔缺损（ASD）和卵圆孔未闭（PFO）装置相关血栓是一种不常见的现象，在封堵术后早期和晚期均可出现。典型的危险因素包括心房颤动、高凝疾病/状态以及装置内皮化不足。我们报告一例有趣的病例，一名15岁女性在肾梗死后来接受了PFO装置封堵，封堵术后3个月发现双房装置血栓形成。她最初接受抗凝和抗血小板治疗，并间断使用全身性组织型纤溶酶原激活剂（tPA），但在血栓完全溶解后又出现了新的左房血栓。她的装置通过手术取出，发现已完全内皮化。她的病例凸显了目前缺乏关于ASD/PFO装置相关血栓的指南。
