Costanza Flavia, Giampietro Antonella, Tartaglione Tommaso, Angelini Flavia, Gaudino Simona, De Marinis Laura, Pontecorvi Alfredo, Chiloiro Sabrina, Bianchi Antonio
Department of Translational Medicine and Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Division of Endocrinology and Metabolism, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Endocr Metab Immune Disord Drug Targets. 2024 Sep 23. doi: 10.2174/0118715303306378240816104619.
Hypophysitis is a rare inflammatory disorder of the pituitary gland. Symptoms and signs of hypophysitis can be various, progressing insidiously, and its recognition may be challenging.
We report the clinical history and therapeutic management of a 59-year-old man diagnosed with arginine vasopressin deficiency (AVP-D) due to an infundibulo-neurohypophysitis (INH) that occurred after the patient had inhaled spray film containing toluene. In consideration of the clinical signs and radiological imaging suggestive of INH, therapy with desmopressin and corticosteroids was instituted, with gradual improvement of polyuria and resolution of the radiological features of INH.
To our knowledge, we described the first case of INH, manifested with AVP-D, secondary to toluene exposure. In addition, the endocrine effects of toluene inhalation were discussed. Finally, given the scarcity of data available, an overview of all the known toxic substances inducing AVP-D was also provided.
垂体炎是一种罕见的垂体炎症性疾病。垂体炎的症状和体征多种多样，进展隐匿，其诊断可能具有挑战性。
我们报告了一名59岁男性的临床病史及治疗情况，该患者因吸入含甲苯的喷雾膜后发生漏斗 - 神经垂体炎（INH），被诊断为精氨酸血管加压素缺乏症（AVP - D）。考虑到提示INH的临床体征和影像学表现，给予去氨加压素和皮质类固醇治疗，多尿症状逐渐改善，INH的影像学特征也得以消退。
据我们所知，我们描述了首例因接触甲苯继发AVP - D表现的INH病例。此外，还讨论了吸入甲苯的内分泌影响。最后，鉴于现有数据稀缺，还提供了所有已知可诱发AVP - D的有毒物质概述。
