Yue Chuan, Gu Li, Guo Wei
Department of Breast Disease Diagnosis and Treatment Center, Central Hospital Affiliated to Shandong First Medical University, No.105, Jiefang Road, Jinan, Shandong Province, 250013, China.
Department of Otolaryngology Head and Neck surgery, Central Hospital Affiliated to Shandong First Medical University, No.105, Jiefang Road, Jinan, Shandong Province, 250013, China.
Endocr Metab Immune Disord Drug Targets. 2024 Sep 23. doi: 10.2174/0118715303304858240904042316.
The involvement of the larynx in many situations can have a substantial impact on a person's voice, breathing, and general health. Individuals with autoimmune thyroid disorders can experience a variety of conditions affecting the larynx. Autoimmune thyroid disorders, such as Hashimoto's thyroiditis [HT] and Graves' disease [GD], are prevalent conditions affecting the thyroid gland. Beyond their established impact on thyroid function, these disorders have been associated with laryngeal involvement. The current study aims to explore the likelihood of laryngeal involvement in patients with Autoimmune Thyroid Disorders [AITD].
This study involved a retrospective analysis of medical records from patients diagnosed with autoimmune thyroid disorders. Inclusion criteria were a confirmed diagnosis through laboratory investigations and clinical assessment. Patients with pre-existing laryngeal pathologies or other conditions affecting the larynx were not considered. We collected data from 4 research articles and 3 clinical trials from Embase, PubMed, and NCBI-Trials portals, focusing on reported laryngeal symptoms. The severity of laryngeal involvement was assessed and categorized based on its extent and impact on vocal function.
Preliminary analysis of the collected data indicated a significant proportion of patients with autoimmune thyroid disorders reporting laryngeal symptoms. Among these patients, various manifestations of laryngeal involvement were observed, including vocal changes, hoarseness, and throat discomfort.
The findings show that laryngeal symptoms may be an underappreciated feature of these diseases, potentially impacting vocal function and quality of life in affected people. Further research is also needed for more precise projections in this direction.
在许多情况下，喉部受累会对人的嗓音、呼吸及整体健康产生重大影响。自身免疫性甲状腺疾病患者可能会出现多种影响喉部的病症。自身免疫性甲状腺疾病，如桥本甲状腺炎[HT]和格雷夫斯病[GD]，是影响甲状腺的常见病症。除了对甲状腺功能的既定影响外，这些疾病还与喉部受累有关。本研究旨在探讨自身免疫性甲状腺疾病[AITD]患者喉部受累的可能性。
本研究对诊断为自身免疫性甲状腺疾病的患者的病历进行回顾性分析。纳入标准是通过实验室检查和临床评估确诊。既往有喉部病变或其他影响喉部的病症的患者不纳入研究。我们从Embase、PubMed和NCBI-试验数据库的4篇研究文章和3项临床试验中收集数据，重点关注报告的喉部症状。根据喉部受累的程度及其对发声功能的影响对其严重程度进行评估和分类。
对收集到的数据进行的初步分析表明，相当一部分自身免疫性甲状腺疾病患者报告有喉部症状。在这些患者中，观察到喉部受累的各种表现，包括嗓音变化、声音嘶哑和咽喉不适。
研究结果表明，喉部症状可能是这些疾病中未被充分认识的一个特征，可能会影响患者的发声功能和生活质量。还需要进一步研究以在这个方向上做出更精确的预测。
