Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Allen Discovery Center for Neuroimmune Interactions, New York, New York, USA; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Allen Discovery Center for Neuroimmune Interactions, New York, New York, USA; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Immunology and Immunotherapy, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
J Invest Dermatol. 2024 Dec;144(12):2634-2644. doi: 10.1016/j.jid.2024.08.018. Epub 2024 Sep 25.
Murine models are vital preclinical and biological tools for studying itch. In this paper, we explore how these models have enhanced our understanding of the mechanisms underlying itch through both acute and chronic itch models. We provide detailed protocols and recommend experimental setups for specific models to guide researchers in conducting itch research. We distinguish between what constitutes a bona fide pruritogen versus a stimulus that causes pruritogen release, an acute itch model versus a chronic itch model, and how murine models can capture aspects of pruritus in human disease. Finally, we highlight how mouse models of itch have transformed our understanding and development of therapeutics for chronic pruritus in patients.
鼠类模型是研究瘙痒的重要临床前和生物学工具。在本文中，我们通过急性和慢性瘙痒模型探讨了这些模型如何通过增强我们对瘙痒机制的理解。我们提供了详细的方案，并为特定模型推荐了实验设置，以指导研究人员进行瘙痒研究。我们区分了真正的致痒原与引起致痒原释放的刺激物、急性瘙痒模型与慢性瘙痒模型，以及鼠类模型如何捕捉人类疾病中瘙痒的各个方面。最后，我们强调了瘙痒的鼠类模型如何改变我们对慢性瘙痒患者治疗方法的理解和开发。
