Zeng Hui, Wang Jia, Qiu Zhiqun, Tan Yao, Huang Yujing, Luo Jiaohua, Shu Weiqun
Department of Environmental Hygiene, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Department of Medical English, College of Basic Medicine, Army Medical University (Third Military Medical University), Chongqing, China.
Biol Trace Elem Res. 2024 Sep 25. doi: 10.1007/s12011-024-04379-y.
Strontium-rich mineral water (strontium > 0.20 mg/L) is the second largest type of mineral water on commercial drinking water market. Exposure to high levels of strontium through drinking water or soil may interfere with calcium metabolism and increase the risk of cardiovascular and skeletal diseases, but no in-depth mechanism has been disclosed to date. Data on liver metabolic alterations in rats resulted from drinking natural high strontium mineral water (strontium 26.06 mg/L, SrHW) or tap water (filtered by activated carbon, strontium 0.49 mg/L, TW) for 3 months were obtained and analyzed with non-targeted metabolomics strategy. Compared with rats drinking TW, those drinking SrHW showed a significant change in 36 liver metabolites. Among them, 33 liver metabolites (including 14 amino acids, 6 carbohydrates, 4 short-chain fatty acids, 4 organic acids, 2 phenylpropanoic acids, 1 fatty acid, 1 peptide, and 1 bile acid) were down-regulated, and 3 (hydroxyphenyllactic acid, propionylcarnitine and S-adenosine homocysteine) were up-regulated. Metabolic pathway analysis showed that aminoacyl-tRNA biosynthesis, valine, leucine and isoleucine biosynthesis, and alanine, aspartate and glutamate metabolism are most impacted. Furthermore, the serum prealbumin content also significantly decreased in rats drinking SrHW. Therefore, changes in liver metabolites and serum protein levels suggested that high concentration of strontium in water was associated with decreased liver protein synthesis; changes in liver metabolites suggested that high strontium was associated with decreased lipid levels. In conclusion, high strontium in water may exert a negative effect on protein synthesis, and further study on the dose-response relationship is necessary.
富锶矿泉水（锶含量>0.20毫克/升）是商业饮用水市场上第二大类型的矿泉水。通过饮用水或土壤接触高浓度的锶可能会干扰钙代谢，并增加心血管疾病和骨骼疾病的风险，但迄今为止尚未揭示其深入机制。获取了大鼠饮用天然高锶矿泉水（锶含量26.06毫克/升，SrHW）或自来水（经活性炭过滤，锶含量0.49毫克/升，TW）3个月后肝脏代谢变化的数据，并采用非靶向代谢组学策略进行分析。与饮用TW的大鼠相比，饮用SrHW的大鼠有36种肝脏代谢物发生了显著变化。其中，33种肝脏代谢物（包括14种氨基酸、6种碳水化合物、4种短链脂肪酸、4种有机酸、2种苯丙酸、1种脂肪酸、1种肽和1种胆汁酸）下调，3种（羟基苯乳酸、丙酰肉碱和S-腺苷同型半胱氨酸）上调。代谢途径分析表明，氨酰-tRNA生物合成、缬氨酸、亮氨酸和异亮氨酸生物合成以及丙氨酸、天冬氨酸和谷氨酸代谢受到的影响最大。此外，饮用SrHW的大鼠血清前白蛋白含量也显著降低。因此，肝脏代谢物和血清蛋白水平的变化表明，水中高浓度的锶与肝脏蛋白质合成减少有关；肝脏代谢物的变化表明，高锶与脂质水平降低有关。总之，水中高锶可能对蛋白质合成产生负面影响，有必要进一步研究剂量反应关系。
