Department of Neurology, MedStar Health-Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC, 20007, USA.
Curr Neurol Neurosci Rep. 2024 Dec;24(12):665-670. doi: 10.1007/s11910-024-01379-2. Epub 2024 Sep 25.
Migraine affects a large portion of the world's population. Migraine encompasses a broad range of symptoms, with broad reaching ramifications in the form of Health-Related Quality of Life (HRQoL) factors. In our review we sought to understand the aspects encompassing the burden of disease on both an individual and population level. Furthermore, we reviewed the development and incorporation of Patient Reported Outcome Measures (PROM), questionnaires that assess HRQoL in real time, in how they have been incorporated in clinical research up to now and how they can be utilized in clinical practice moving forward.
It has been shown that there is much heterogeneity within the field in PROM development processes as well as their utilization in episodic migraine (EM) clinical trials. Furthermore, they are inconsistently used in clinical practice. Among the most commonly used PROMs, the MSQv2.1 is among the most valid and reliable. Beyond that, it also shows promise to help in guidance of clinical management of migraine.
偏头痛影响了世界上很大一部分人口。偏头痛包含了广泛的症状，其对健康相关生活质量（HRQoL）因素也有着广泛的影响。在我们的综述中，我们试图了解疾病在个体和人群层面上的负担。此外，我们还综述了患者报告结局测量（PROM）的发展和应用，这些问卷实时评估 HRQoL，以及它们迄今为止在临床研究中是如何被应用的，以及它们如何在未来的临床实践中被利用。
已经表明，在 PROM 开发过程及其在发作性偏头痛（EM）临床试验中的应用方面，该领域存在很大的异质性。此外，它们在临床实践中使用不一致。在最常用的 PROM 中，MSQv2.1 是最有效和可靠的。除此之外，它还有望帮助指导偏头痛的临床管理。
