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三级大都市医院手术后出院镇痛指南对出院阿片类药物处方的影响。

Effectiveness of a discharge analgesia guideline on discharge opioid prescribing after a surgical procedure from a tertiary metropolitan hospital.

机构信息

Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Camperdown, New South Wales, Australia. ORCID: https://orcid.org/0000-0002-7412-0123.

Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Camper-down; Department of Pharmacy, Prince of Wales Hospital, Randwick, New South Wales, Australia.

出版信息

J Opioid Manag. 2024 Jul-Aug;20(4):329-338. doi: 10.5055/jom.0863.

Abstract

OBJECTIVE

The primary objective of this study was to evaluate the effectiveness of a discharge analgesia guideline on the number of days' supply of opioid analgesics provided among surgical patients upon hospital discharge. The secondary objective was to analyze the effect of this guideline on the provision of an analgesic discharge plan.

DESIGN

A retrospective historical control cohort study.

SETTING

A tertiary metropolitan hospital.

INTERVENTIONS

A discharge analgesia guideline recommending the supply of opioid analgesics on discharge based on patient use in the 24 hours prior to discharge and the supply of an analgesic discharge plan.

MAIN OUTCOME MEASURE(S): The primary outcome measure was the number of days' supply of opioids. The secondary outcome measure was the proportion of patients receiving an analgesic discharge plan.

RESULTS

There was no change in the number of days' supply of opioids provided on discharge (median, interquartile range: 5, 3-9.75 vs 6, 4-10; p = 0.107) and in the proportion of patients receiving an analgesic discharge plan (26 percent vs 22.2 percent; p = 0.604). The results of two multivariable regression models showed no change in the number of days' supply of opioids (adjusted incidence rate ratio, 95 percent confidence interval [CI]: 1.1, 0.9-1.2) and the provision of an analgesic discharge plan (adjusted odds ratio, 95 percent CI: 0.6, 0.2-1.4) after adjusting for confounding variables.

CONCLUSION

Overall, our study found no change in the number of days' supply of opioids provided on discharge and the provision of an analgesic discharge plan after implementation of a discharge analgesia guideline, but we also found that prescribing practices already aligned with the guideline before its implementation.

摘要

目的

本研究的主要目的是评估出院镇痛指南对术后患者出院时提供的阿片类镇痛药供应天数的影响。次要目的是分析该指南对提供镇痛出院计划的影响。

设计

回顾性历史对照队列研究。

设置

三级大都市医院。

干预措施

出院镇痛指南建议根据患者在出院前 24 小时内的使用情况以及提供镇痛出院计划来供应阿片类镇痛药。

主要观察指标

主要观察指标为阿片类药物的供应天数。次要观察指标为接受镇痛出院计划的患者比例。

结果

出院时提供的阿片类药物供应天数(中位数,四分位距:5,3-9.75 与 6,4-10;p = 0.107)和接受镇痛出院计划的患者比例(26%与 22.2%;p = 0.604)均无变化。两项多变量回归模型的结果表明,阿片类药物供应天数(调整发病率比,95%置信区间[CI]:1.1,0.9-1.2)和镇痛出院计划的提供(调整优势比,95%CI:0.6,0.2-1.4)均无变化,在调整混杂变量后。

结论

总体而言,我们的研究发现,实施出院镇痛指南后,出院时提供的阿片类药物供应天数和提供镇痛出院计划没有变化,但我们也发现,在该指南实施之前,处方实践已经与该指南一致。

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