Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing 100191, China; Peking University First Hospital, Peking University Health Science Center, Beijing 100034, China; Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing 100191, China.
Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Int Immunopharmacol. 2024 Dec 5;142(Pt B):113248. doi: 10.1016/j.intimp.2024.113248. Epub 2024 Sep 24.
Most somatic cells secrete vesicles called exosomes, which contain a variety of biomolecules. Recent research indicates that macrophage-derived exosomes are strongly correlated with tumors, infectious diseases, chronic inflammation, and tissue fibrosis. Therefore, the purpose of this review is to delve into the mechanisms of pathological states and how macrophage-derived exosomes react to them. We also discuss the biological effects of exosomes and how they affect disease. In addition, we have examined the possible uses of exosomes in illness treatment, highlighting both the benefits and drawbacks of these applications.
大多数体细胞都会分泌一种称为外泌体的囊泡，其中包含多种生物分子。最近的研究表明，巨噬细胞来源的外泌体与肿瘤、传染病、慢性炎症和组织纤维化密切相关。因此，本综述的目的是深入探讨病理状态的机制以及巨噬细胞来源的外泌体如何对其作出反应。我们还讨论了外泌体的生物学效应以及它们如何影响疾病。此外，我们还研究了外泌体在疾病治疗中的可能应用，强调了这些应用的优点和缺点。
