Elsamadicy Aladine A, Sadeghzadeh Sina, Serrato Paul, Sayeed Sumaiya, Hengartner Astrid C, Belkasim Selma, Khalid Syed I, Lo Sheng-Fu Larry, Sciubba Daniel M
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut, USA.
School of Medicine, Stanford University, Stanford, California, USA.
World Neurosurg. 2024 Dec;192:e292-e305. doi: 10.1016/j.wneu.2024.09.089. Epub 2024 Oct 11.
This study investigates the predictive values of the Risk Analysis Index (RAI), the modified 5-item Frailty Index (mFI-5), and advanced age for predicting 30-day extended length of stay (LOS), 30-day complications, and readmissions in patients undergoing posterior spinal fusion (PSF) for adult spinal deformity (ASD).
A retrospective cohort study was performed using the 2012-2021 American College of Surgeons National Surgical Quality Improvement Program database. Adults undergoing PSF for ASD were identified using Current Procedural Terminology and International Classification of Diseases codes. Using receiver operating characteristic and multivariable analyses, we compared the discriminative thresholds and independent associations of RAI, mFI-5, and greater patient age for extended LOS, 30-day complications, and readmissions.
In this cohort of 3814 patients, RAI identified 90.7% as Robust, 6.0% as Normal, and 3.3% as Frail/Very frail, while mFI-5 classified 47.1% as Robust, 37.5% as Normal, and 15.3% as Frail/Very frail. Multivariable analysis revealed both RAI and mFI-5 as significant predictors of extended LOS for Normal (RAI: P < 0.001; mFI-5: P = 0.013) and Frail/Very frail patients (RAI: P < 0.001; mFI-5: P = 0.003). Additionally, RAI was a significant predictor of 30-day complication risk for Normal patients (P = 0.005). Furthermore, mFI-5 was a significant predictor of 30-day readmission among Frail/Very frail patients (P = 0.002).
This study suggests that the utility of RAI and mFI-5 in predicting extended LOS patients undergoing PSF for ASD. RAI was found to be superior to mFI-5 for predicting 30-day readmissions, while mF-5 was greater for 30-day complications. These findings highlight the need for future studies to identify optimal methods in incorporating frailty assessments into preoperative surgical planning and patient discussions.
本研究调查风险分析指数(RAI)、改良的5项衰弱指数(mFI-5)和高龄对预测成人脊柱畸形(ASD)后路脊柱融合术(PSF)患者30天延长住院时间(LOS)、30天并发症和再入院情况的预测价值。
使用2012 - 2021年美国外科医师学会国家外科质量改进计划数据库进行一项回顾性队列研究。通过当前手术操作术语和国际疾病分类代码识别接受ASD的PSF手术的成年人。使用受试者工作特征曲线和多变量分析,我们比较了RAI、mFI-5和更高患者年龄对延长LOS、30天并发症和再入院情况的判别阈值和独立关联。
在这3814例患者队列中,RAI将90.7%识别为强健,6.0%为正常,3.3%为衰弱/非常衰弱,而mFI-5将47.1%分类为强健,37.5%为正常,15.3%为衰弱/非常衰弱。多变量分析显示,RAI和mFI-5均为正常患者(RAI:P < 0.001;mFI-5:P = 0.013)和衰弱/非常衰弱患者延长LOS的显著预测因素(RAI:P < 0.001;mFI-5:P = 0.003)。此外,RAI是正常患者30天并发症风险的显著预测因素(P = 0.005)。此外,mFI-5是衰弱/非常衰弱患者30天再入院的显著预测因素(P = 0.002)。
本研究表明RAI和mFI-5在预测接受ASD的PSF手术患者延长LOS方面的效用。发现RAI在预测30天再入院方面优于mFI-5,而mF-5在预测30天并发症方面表现更佳。这些发现凸显了未来研究在将衰弱评估纳入术前手术规划和患者讨论中确定最佳方法的必要性。