Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo 153-8902, Japan; University of Tokyo Institute for Diversity & Adaptation of Human Mind (UTIDAHM), Tokyo 153-8902, Japan.
Department of Neuropsychiatry, Graduate School of Wakayama Medical University, Wakayama 649-7113, Japan.
Neuroimage. 2024 Oct 15;300:120867. doi: 10.1016/j.neuroimage.2024.120867. Epub 2024 Sep 24.
Recent technical developments have led to the invention of multiband functional magnetic resonance imaging (fMRI) sequences that allow for faster sampling rates. However, some studies have highlighted problems with these sequences, leading to a decreased temporal signal-to-noise ratio (tSNR). In addition, this temporal noise may interfere with detecting reward-related responses in mesolimbic regions. The blood-oxygen-level-dependent signal utilized in the majority of fMRI measurements is relatively slow. Furthermore, the cerebral response to gustatory stimuli would also be relatively slow. Therefore, given the temporal noise issues with multiband sequences, it is unclear whether multiband sequences are necessary for fMRI studies using gustatory stimuli. We thus conducted an fMRI experiment using a gustatory stimulus to investigate the effects of multiband sequences and increased sampling rates on statistical outcome measures. A single-band sequence with a repetition time (TR) of 2 s of phantom fMRI data and gustatory fMRI data from the gustatory regions exhibited the highest tSNR, although the tSNR of this sequence of gustatory fMRI was not statistically different from tSNR of multiband sequences with a TR of 2 s in any of the selected region of interests. Conventional general linear model analysis of fMRI showed that single-band sequences are more advantageous than multiband sequences for detecting brain responses to gustatory stimuli in the primary gustatory cortex. In addition, a Bayesian data comparison showed that data derived from a single-band sequence with a TR of 2 s was optimal for inferring neuronal connectivity in gustatory processing. Therefore, a conventional single-band sequence with a TR of 2 s is more appropriate for fMRI with gustatory stimuli. Image acquisition sequences should be selected aligned with the study objectives and target brain regions.
最近的技术发展导致了多波段功能磁共振成像（fMRI）序列的发明，这些序列允许更快的采样率。然而，一些研究强调了这些序列存在问题，导致时间信号噪声比（tSNR）降低。此外，这种时间噪声可能会干扰中脑边缘区域中与奖励相关的反应的检测。在大多数 fMRI 测量中使用的血氧水平依赖信号相对较慢。此外，大脑对味觉刺激的反应也会相对较慢。因此，鉴于多波段序列存在时间噪声问题，尚不清楚使用味觉刺激的 fMRI 研究是否需要多波段序列。因此，我们使用味觉刺激进行了 fMRI 实验，以研究多波段序列和增加采样率对统计结果测量的影响。在 Phantom fMRI 数据和味觉 fMRI 数据中，重复时间（TR）为 2 秒的单波段序列表现出最高的 tSNR，尽管味觉 fMRI 的这种单波段序列的 tSNR在任何所选的感兴趣区域中均与 2 秒 TR 的多波段序列的 tSNR无统计学差异。味觉刺激的大脑反应。此外，fMRI 的贝叶斯数据分析表明，对于检测初级味觉皮层中味觉刺激的大脑反应，单波段序列比多波段序列更有利。此外，贝叶斯数据分析表明，源自 TR 为 2 秒的单波段序列的数据对于推断味觉处理中的神经元连接性是最佳的。因此，用于 fMRI 的常规单波段序列（TR 为 2 秒）更适合具有味觉刺激的 fMRI。图像采集序列应根据研究目标和目标脑区进行选择。
