Kobayashi Y, Hirai H, Okabe T, Urabe A, Takaku F
Jpn J Cancer Res. 1985 Sep;76(9):796-8.
Using a beta-chain cDNA probe of the T-cell receptor, we detected T-cell receptor gene rearrangement in leukemic cells from an adult patient with common acute lymphocytic leukemia (cALL). The leukemic cells expressed non-T, non-B cell marker profiles (CALLA+, J5+, Leu-1-, Leu-4-, Ia+, B1-, c-Ig mu- and TdT+). This is the first reported case of cALL with T-cell receptor gene rearrangement and/or deletion.
我们使用T细胞受体的β链cDNA探针，检测了一名成年普通急性淋巴细胞白血病（cALL）患者白血病细胞中的T细胞受体基因重排。白血病细胞表达非T、非B细胞标志物谱（CALLA+、J5+、Leu-1-、Leu-4-、Ia+、B1-、c-Ig mu-和TdT+）。这是首例报道的伴有T细胞受体基因重排和/或缺失的cALL病例。
