Ha K, Minden M, Hozumi N, Gelfand E W
J Clin Invest. 1984 Apr;73(4):1232-6. doi: 10.1172/JCI111310.
A 6-yr-old girl with T cell acute lymphoblastic leukemia (ALL) is described. She had a mediastinal mass and her leukemic cells expressed T cell-associated antigens (Leu 1+, OKT3+, OKT9+, and OKT10+). When we examined genomic DNA from the leukemic cells, we detected Ig mu-chain gene rearrangement with germ-line configuration of light chain genes. As reported recently, detecting Ig gene rearrangement has become an important procedure for further classifying B cell precursor cells. This case, however, suggests that there is also heterogeneity among patients with T cell ALL, not only at the level of cell surface phenotypes, but also at the level of the Ig gene. These findings have major implications when we consider both the ontogenesis of these leukemic cells and the normal differentiation of human lymphocytes.
本文描述了一名患有T细胞急性淋巴细胞白血病（ALL）的6岁女孩。她有纵隔肿块，其白血病细胞表达T细胞相关抗原（Leu 1+、OKT3+、OKT9+和OKT10+）。当我们检测白血病细胞的基因组DNA时，我们检测到Ig μ链基因重排，轻链基因呈种系构型。正如最近报道的那样，检测Ig基因重排已成为进一步分类B细胞前体细胞的重要程序。然而，该病例表明，T细胞ALL患者之间也存在异质性，不仅在细胞表面表型水平，而且在Ig基因水平。当我们考虑这些白血病细胞的发生以及人类淋巴细胞的正常分化时，这些发现具有重要意义。
