Nakajima T, Maeno M, Takahashi T, Yoshimoto M, Nishi M
Jpn J Cancer Res. 1985 Sep;76(9):880-6.
To elucidate how low-mobility T cells emerge in the peripheral blood of cancer patients, lymphocytes from normal individuals were treated with cancer patients' plasma, immunosuppressive (IS) substance with or without interleukin-2, or neuraminidase. A delay in cell mobility was induced by IS substance and neuraminidase treatments, which degrade the cell surface charge. Compared to the normal mobility pattern of lymphocytes, patterns induced by these treatments were characterized by a general shift of the fast cell peak to the left side. These patterns were different from those of cancer patients in terms of the inverse relationship between slow and fast peaks. These results indicate that, though humoral factors in the peripheral blood of cancer patients take a partial role, other mechanisms might operate to induce the characteristic mobility pattern of lymphocytes. One of the possibilities, the emerging of a special T cell subset recruited from the thymus, is discussed.
为阐明癌症患者外周血中低迁移率T细胞是如何出现的，将正常个体的淋巴细胞用癌症患者的血浆、含或不含白细胞介素-2的免疫抑制（IS）物质或神经氨酸酶进行处理。IS物质和神经氨酸酶处理可诱导细胞迁移延迟，这两种物质会降解细胞表面电荷。与淋巴细胞的正常迁移模式相比，这些处理诱导的模式的特征是快速细胞峰总体向左移动。就慢峰和快峰之间的反比关系而言，这些模式与癌症患者的模式不同。这些结果表明，尽管癌症患者外周血中的体液因子起部分作用，但可能有其他机制诱导淋巴细胞的特征性迁移模式。其中一种可能性是，从胸腺募集的特殊T细胞亚群的出现，对此进行了讨论。
