Effectiveness of Pneumococcal Conjugate Vaccines Over Antibiotic-Resistant Acute Otitis Media in Children: A Systematic Review.

One of the most prevalent childhood illnesses in the world, acute otitis media (AOM), is mainly brought on by , which has resulted in a significant increase in the use of antibiotics and the emergence of antibiotic-resistant (ABR) strains. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 criteria served as the foundation for this systematic review. We conduct a comprehensive literature search across five primary databases, including PubMed, PubMed Central, Cochrane, Science Direct, and Google Scholar, to identify eligible studies assessing the impact of pneumococcal conjugate vaccines (PCVs) on AOM incidence and ABR. Data on AOM rates, shifts in serotype distribution, and the prevalence of ABR pneumococcal strains in children under the age of 18 after PCV implementation are taken from all kinds of studies that assessed any pneumococcal conjugate vaccines (PCV 7, 10, and 13) as interventions. Eighteen records are identified as eligible for the final review. Other articles are excluded by assessing the title and abstract relevancy, applying inclusion criteria, and using critical appraisal tools. Implementing PCVs among children in the national immunization programs in most countries, particularly PCV13 has led to substantial decreases in ABR strains. However, serotype replacement has emerged as a challenge, with non-vaccine serotypes becoming more prevalent. Despite this, the overall burden of antibiotic resistance and AOM has decreased, underscoring the positive impact of PCVs on public health. PCVs effectively reduce the incidence of AOM and the prevalence of ABR in children. The vaccines play a crucial role in antibiotic stewardship by decreasing the need for broad-spectrum antibiotics. Continued surveillance and development of next-generation vaccines are essential to address serotype replacement and sustain the benefits of PCVs in combating antibiotic-resistant AOM.