Sun Yuyan, Lu Bing, Hu Yuanwen, Lv Yingqi, Zhong Shao
Department of Endocrinology, Gusu School, Nanjing Medical University, The First People's Hospital of Kunshan, Kunshan, 215300, People's Republic of China.
Department of Gastroenterology, The First People's Hospital of Kunshan, Kunshan, 215300, People's Republic of China.
Int J Gen Med. 2024 Sep 21;17:4297-4309. doi: 10.2147/IJGM.S477497. eCollection 2024.
In recent years, pancreatogenic diabetes mellitus has garnered significant attention due to its high incidence, complications, and mortality rates. Glycemic variability (GV) can increase the risk of pancreatogenic diabetes mellitus and its associated complications; however, the precise mechanism remains unclear. The effective control of GV is crucial for preventing the onset of pancreatic diabetes mellitus and improving prognosis. Both diet and antidiabetic medications have substantial effects on GV. However, many patients are prescribed suboptimal or even harmful drugs. Therefore, to provide a comprehensive treatment basis for clinicians to prevent and treat pancreatogenic diabetes mellitus, this study aimed to elucidate the relationship between GV and pancreatogenic diabetes mellitus; investigate the potential mechanisms (such as oxidative stress, inflammatory response, insulin resistance, and lipid metabolism disorders); provide lifestyle guidance; and recommend drug selections to reduce the GV in patients with pancreatogenic diabetes mellitus.
近年来，胰源性糖尿病因其高发病率、并发症和死亡率而备受关注。血糖变异性（GV）会增加胰源性糖尿病及其相关并发症的风险；然而，确切机制仍不清楚。有效控制GV对于预防胰腺糖尿病的发生和改善预后至关重要。饮食和抗糖尿病药物对GV都有显著影响。然而，许多患者被开具了次优甚至有害的药物。因此，为临床医生预防和治疗胰源性糖尿病提供全面的治疗依据，本研究旨在阐明GV与胰源性糖尿病之间的关系；探讨潜在机制（如氧化应激、炎症反应、胰岛素抵抗和脂质代谢紊乱）；提供生活方式指导；并推荐药物选择以降低胰源性糖尿病患者的GV。
