Murfin D J, Choromanski L, Kuhn R E
J Parasitol. 1985 Oct;71(5):525-9.
Six clones and 4 subclones were isolated from the Brazil strain of Trypanosoma cruzi and were passaged in C3H(He) mice. Parasitemia levels and survival times of mice infected with 8 of the isolates were equivalent to the Brazil strain in virulence. Two clones, designated WFTc-5.1 and WFTc-6.1 (WFTc = Wake Forest Trypanosoma cruzi) were of lower virulence in C3H mice than the other isolates and the Brazil strain. C57BL/6 mice infected with WFTc-5.1 had significantly lower parasitemias and higher survival rates than C57BL/6 mice infected with the Brazil strain or a clone designated WFTc-3.2. Levels of anti-T. cruzi IgM and IgG antibodies were the same in mice infected with higher virulence or lower virulence isolates. Based on these results the Brazil strain of T. cruzi is composed of distinct subpopulations which are heterogeneous with respect to virulence.
从克氏锥虫巴西株中分离出6个克隆和4个亚克隆，并在C3H(He)小鼠中传代。感染8种分离株的小鼠的寄生虫血症水平和存活时间在毒力上与巴西株相当。两个克隆，命名为WFTc-5.1和WFTc-6.1（WFTc = 维克森林克氏锥虫）在C3H小鼠中的毒力低于其他分离株和巴西株。感染WFTc-5.1的C57BL/6小鼠的寄生虫血症明显低于感染巴西株或命名为WFTc-3.2的克隆的C57BL/6小鼠，存活率更高。感染高毒力或低毒力分离株的小鼠中抗克氏锥虫IgM和IgG抗体水平相同。基于这些结果，克氏锥虫巴西株由不同的亚群组成，这些亚群在毒力方面是异质的。
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