Ritter D M, Rowland E C
J Parasitol. 1984 Oct;70(5):755-9.
The study of the parameters affecting Corpus Christi strain-induced protection in C3H(He) mice against Brazil strain T. cruzi infection is reported herein. A dose of 10(7) Corpus Christi epimastigotes was found to be the most effective dose for protection. Vaccination of mice 5 days to 11 wk prior to infection was determined to be the optimal time interval for protection. The subcutaneous route for vaccination and infection provides the most effective protection to experimental animals. Multiple inoculations with Corpus Christi, whether live or freeze thawed, increased the protective effect only slightly. The Corpus Christi strain of T. cruzi has proved to be quite suitable in providing protection to highly susceptible C3H(He) mice against an infection with the virulent Brazil strain of T. cruzi.
本文报道了影响克珀斯克里斯蒂株诱导C3H(He)小鼠对巴西株克氏锥虫感染产生保护作用的参数研究。发现10(7)剂量的克珀斯克里斯蒂前鞭毛体是最有效的保护剂量。确定在感染前5天至11周对小鼠进行疫苗接种是产生保护作用的最佳时间间隔。皮下接种和感染途径能为实验动物提供最有效的保护。用克珀斯克里斯蒂株多次接种，无论活的还是冻融的，仅略微增加保护效果。克氏锥虫的克珀斯克里斯蒂株已被证明非常适合为高度易感的C3H(He)小鼠提供针对强毒巴西株克氏锥虫感染的保护。
