经过数年强化群体药物给药后，人类宿主群体中土源性蠕虫的聚集模式。
Patterns of soil-transmitted helminth aggregation in the human host population after several years of intensive mass drug administration.
作者信息
Mayer Julia, Collyer Benjamin S, Maddren Rosie, Abtew Birhan, Liyew Ewnetu Firdawek, Chernet Melkie, Tollera Getachew, Tasew Geremew, Anderson Roy M
机构信息
Department of Infectious Disease Epidemiology, Imperial College London, School of Public Health Building, 90 Wood Lane, London W12 0BZ, UK.
Bacterial, Parasitic and Zoonotic Disease Research Directorate, Ethiopian Public Health Institute, Swaziland Street, 2PWJ P8C, Addis Ababa, Ethiopia.
出版信息
Trans R Soc Trop Med Hyg. 2024 Dec 3;118(12):829-831. doi: 10.1093/trstmh/trae059.
BACKGROUND
Community-wide mass drug administration (cMDA) is known as an effective, albeit costly, control strategy for soil-transmitted helminth (STH) parasites. A better understanding of STH aggregation after many rounds of cMDA could help shape more cost-effective policies.
METHODS
This analysis uses data from the Geshiyaro project, aiming to break STH transmission by cMDA and water, sanitation and hygiene interventions. Ascaris lumbricoides infection prevalence is derived from egg count data and parasite aggregation is obtained by fitting a negative binomial distribution to the frequency distribution of faecal egg counts.
RESULTS
The relationship between parasite dispersion and infection prevalence is approximately linear. Parasite aggregation increases as infection prevalence decreases.
CONCLUSIONS
A minority of individuals carry most parasites as prevalence decreases in the community. These individuals could be selectively targeted for repeated treatment.
背景
社区范围内的大规模药物给药（cMDA）是一种已知的针对土壤传播蠕虫（STH）寄生虫的有效控制策略，尽管成本高昂。更好地了解多轮cMDA后STH的聚集情况有助于制定更具成本效益的政策。
方法
本分析使用了来自格希亚罗项目的数据，旨在通过cMDA以及水、环境卫生和个人卫生干预措施来阻断STH传播。蛔虫感染率来自虫卵计数数据，通过将负二项分布拟合到粪便虫卵计数的频率分布来获得寄生虫聚集情况。
结果
寄生虫离散度与感染率之间的关系大致呈线性。随着感染率降低，寄生虫聚集增加。
结论
随着社区感染率下降，少数个体携带了大多数寄生虫。这些个体可被选择性地作为重复治疗的目标。
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