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多西他赛诱导的转移性肺腺癌患者肺炎

Docetaxel-Induced Pneumonitis in a Patient With Metastatic Lung Adenocarcinoma.

作者信息

Chua Brian, Tan Yi Hern

机构信息

Respiratory & Critical Care Medicine, Singapore General Hospital, Singapore, SGP.

出版信息

Cureus. 2024 Aug 27;16(8):e67939. doi: 10.7759/cureus.67939. eCollection 2024 Aug.

DOI:10.7759/cureus.67939
PMID:39328636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11426334/
Abstract

Docetaxel is a taxane anti-neoplastic agent commonly used in the treatment of solid-organ tumours. Here, we describe a case of a patient with metastatic lung adenocarcinoma who had disease progression following initial treatment with a combination of pembrolizumab, pemetrexed and carboplatin. She received three cycles of docetaxel and had a favourable oncological response but was admitted for breathlessness following the third cycle. A repeat computed tomography scan of the thorax showed predominantly right-sided ground-glass opacities and consolidation. The patient underwent high-risk bronchoscopy and bronchoalveolar lavage. Once infection was confidently ruled out, she was started on high-dose steroid therapy and responded to treatment.

摘要

多西他赛是一种紫杉烷类抗肿瘤药物，常用于实体器官肿瘤的治疗。在此，我们描述了一例转移性肺腺癌患者的病例，该患者在接受帕博利珠单抗、培美曲塞和卡铂联合初始治疗后疾病进展。她接受了三个周期的多西他赛治疗，肿瘤学反应良好，但在第三个周期后因呼吸困难入院。胸部计算机断层扫描复查显示主要为右侧磨玻璃影和实变。患者接受了高风险支气管镜检查和支气管肺泡灌洗。一旦明确排除感染，就开始对她进行高剂量类固醇治疗，她对治疗有反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e677/11426334/befb2e936a93/cureus-0016-00000067939-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e677/11426334/ff8f0790f568/cureus-0016-00000067939-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e677/11426334/a2c135df868c/cureus-0016-00000067939-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e677/11426334/befb2e936a93/cureus-0016-00000067939-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e677/11426334/ff8f0790f568/cureus-0016-00000067939-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e677/11426334/a2c135df868c/cureus-0016-00000067939-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e677/11426334/befb2e936a93/cureus-0016-00000067939-i03.jpg

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本文引用的文献

1
Taxane-induced acute interstitial pneumonitis in patients with breast cancer and outcome of taxane rechallenge.乳腺癌患者中紫杉烷诱导的急性间质性肺炎及再次使用紫杉烷的结果
Lung India. 2022 Mar-Apr;39(2):158-168. doi: 10.4103/lungindia.lungindia_126_21.
2
Docetaxel-induced interstitial lung disease among patients with breast cancer: a case series and review of literature.多西他赛诱导的乳腺癌患者间质性肺疾病：病例系列及文献综述
Respirol Case Rep. 2021 Jun 13;9(7):e00802. doi: 10.1002/rcr2.802. eCollection 2021 Jul.
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药物性间质性肺疾病：一项系统评价
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Docetaxel-related interstitial pneumonitis.多西他赛相关的间质性肺炎。
Ther Clin Risk Manag. 2015 Dec 9;11:1813-6. doi: 10.2147/TCRM.S90488. eCollection 2015.
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Pneumonitis and pulmonary fibrosis in a patient receiving adjuvant docetaxel and cyclophosphamide for stage 3 breast cancer: a case report and literature review.一名接受多西他赛和环磷酰胺辅助治疗的III期乳腺癌患者发生肺炎和肺纤维化：病例报告及文献综述
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Docetaxel and interstitial pulmonary injury.
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