Li Shichao, Gao Mengmeng, He Kangwen, Yuan Guanjie, Yin Ting, Hu Daoyu, Li Zhen
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
MR Collaborations, Siemens Healthineers Ltd., Chengdu 610041, China.
Bioengineering (Basel). 2024 Sep 7;11(9):901. doi: 10.3390/bioengineering11090901.
Accurate prediction of renal mass subtypes, along with the WHO/ISUP grade and pathological T (pT) stage of clear cell renal cell carcinoma (ccRCC), is crucial for optimal decision making. Our study aimed to investigate the feasibility and reproducibility of motion-robust radial T2 mapping in differentiating lipid-poor angiomyolipoma (MFAML) from RCC and characterizing the WHO/ISUP grade and pT stage of ccRCC. Finally, 92 patients undergoing renal radial T2 mapping and ZOOMit DWI were recruited. The T2 values and apparent diffusion coefficient (ADC) were analyzed. Correlation coefficients were calculated between ADC and T2 values. Notably, ccRCC exhibited higher T2 and ADC values than MFAML ( < 0.05). T2 values were lower in the higher WHO/ISUP grade and pT stage of ccRCC (all < 0.05). ADC showed no significant difference for pT stage ( = 0.056). T2 values revealed a higher area under the curve (AUC) in evaluating the WHO/ISUP grade compared to ADC (0.936 vs. 0.817, = 0.027). T2 values moderately positively correlated with ADC (r = 0.675, < 0.001). In conclusion, quantitative motion-robust radial T2 mapping is feasible for characterizing solid renal masses and could provide additional value for multiparametric imaging in predicting WHO/ISUP grade and pT stage of ccRCC.
准确预测肾肿块亚型以及透明细胞肾细胞癌（ccRCC）的WHO/ISUP分级和病理T（pT）分期，对于做出最佳决策至关重要。我们的研究旨在探讨运动稳健的径向T2映射在区分乏脂性血管平滑肌脂肪瘤（MFAML）与肾细胞癌以及表征ccRCC的WHO/ISUP分级和pT分期方面的可行性和可重复性。最终，招募了92例行肾径向T2映射和ZOOMit DWI检查的患者。分析了T2值和表观扩散系数（ADC）。计算了ADC与T2值之间的相关系数。值得注意的是，ccRCC的T2值和ADC值均高于MFAML（<0.05）。ccRCC的WHO/ISUP分级和pT分期越高，T2值越低（均<0.05）。ADC在pT分期方面无显著差异（=0.056）。在评估WHO/ISUP分级时，T2值的曲线下面积（AUC）高于ADC（0.936对0.817，=0.027）。T2值与ADC呈中度正相关（r = 0.675，<0.001）。总之，定量运动稳健的径向T2映射对于表征实性肾肿块是可行的，并且在预测ccRCC的WHO/ISUP分级和pT分期方面可为多参数成像提供额外价值。
