Division of Gynecologic Oncology, Mayo Clinic, Rochester, MN 55902, USA.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55902, USA.
Curr Oncol. 2024 Sep 17;31(9):5557-5572. doi: 10.3390/curroncol31090412.
Endometrial cancer (EC) patients make up the second largest group of female cancer survivors. Patient-reported outcomes (PROs) including quality of life (QOL) and sexual function and satisfaction (SF and S) are critical facets of survivorship. This prospective, longitudinal study assesses associations between baseline characteristics and PROs after treatment. Herein, we report the baseline clinical characteristics and PROs prior to treatment initiation. Outcomes post-treatment over time will be reported separately. Patients with planned surgery for EC were prospectively enrolled in 2019-2021 and administered the European Organization for Research and Treatment of Cancer (EORTC) QOL Questionnaire Core 30 (QLQ-C30), EORTC QLQ EC Module (EN24), Patient-Reported Outcomes Measurement Information System (PROMIS), and the Mayo Clinic lower extremity lymphedema (LEL) questionnaire. This study enrolled 198 patients with a mean (SD) age of 63.6 (9.8) years and body mass index of 35.5 (8.3) kg/m. No significant differences in the PROs for the QOL were seen when compared to the reference means (SD) except for the lower interest in sexual activity (31.9 (9.8) vs. 47.5 (SE0.70)) and lower fatigue (21.3 (19.8) vs. 31.7 (25.9)). Increased obesity was associated with an increased likelihood of LEL ( < 0.01) and multiple QOL scales, including poorer global health status ( < 0.01) and physical functioning ( < 0.01). Prior to treatment initiation for EC, the patients had a similar QOL compared to that of the general population. The patients with increasing obesity, a known risk factor for EC, had worse overall global health status and physical functioning. A better understanding of these QOL measures is imperative for earlier identification and intervention of patients at risk of chronic impairments from EC treatment.
子宫内膜癌（EC）患者构成了女性癌症幸存者中的第二大群体。患者报告的结局（PROs），包括生活质量（QOL）和性功能及满意度（SF 和 S），是生存的关键方面。这项前瞻性、纵向研究评估了治疗前基线特征与 PROs 之间的关系。在此，我们报告治疗前的基线临床特征和 PROs。治疗后随时间推移的结果将单独报告。2019 年至 2021 年，计划接受 EC 手术的患者前瞻性入组，并接受欧洲癌症研究与治疗组织（EORTC）生活质量问卷核心 30 项（QLQ-C30）、EORTC EC 模块（EN24）、患者报告结局测量信息系统（PROMIS）和梅奥诊所下肢淋巴水肿（LEL）问卷。本研究共纳入 198 例患者，平均（SD）年龄 63.6（9.8）岁，体重指数 35.5（8.3）kg/m²。除对性活动的兴趣较低（31.9（9.8）比 47.5（SE0.70））和疲劳感较低（21.3（19.8）比 31.7（25.9））外，PROs 的 QOL 与参考平均值（SD）相比无显著差异。肥胖程度增加与 LEL（<0.01）和多个 QOL 量表的发生几率增加相关，包括总体健康状况较差（<0.01）和身体功能下降（<0.01）。在开始 EC 治疗之前，患者的 QOL 与一般人群相似。已知肥胖是 EC 的一个危险因素，肥胖程度增加的患者总体健康状况和身体功能更差。更好地了解这些 QOL 指标对于早期识别和干预 EC 治疗后有慢性损伤风险的患者至关重要。
