Özcan Nida, Orakdogen Nermin
Department of Chemistry, Graduate School of Science Engineering and Technology, Istanbul Technical University, 34469 Istanbul, Turkey.
Soft Materials Research Laboratory, Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469 Istanbul, Turkey.
Gels. 2024 Aug 28;10(9):556. doi: 10.3390/gels10090556.
An alternative synthetic pathway was proposed for the optimization of synthesis to find a better correlation between the swelling and elasticity of hyaluronic acid-interpenetrated gels via temperature regulation. An experimental design methodology was presented for the synthesis of polyacrylamide/poly(acrylic acid sodium salt)/hyaluronic acid, PAAm/PSA/HyA, gels by modifying the one-pot procedure using free radical crosslinking copolymerization of AAm with the addition of anionic linear PSA chains in the presence of various amount of HyA, ranging between 0.05% and 0.20% (/). Semi-interpenetrated polymer network (IPN)-structured gels were designed with tunable elasticity, in which the extent of covalent crosslinking interactions is controlled by polymerization temperature ranging between -18 and 45 °C. Depending on the HyA content added in the synthesis and the polymerization temperature, the swelling ratio could be controlled. The addition of 0.05% (/) HyA increased the swelling of semi-IPNs, while the elastic modulus increased with increasing HyA content and decreased with the polymerization temperature. PAAm/PSA/HyA semi-IPNs showed the typical pH-sensitive swelling of anionic gels, and the swelling reached a maximum at a pH of 11.2. PAAm/PSA/HyA gels were tested for the removal of methyl violet from wastewater. Adsorption kinetics were shown to be well-fitted with the pseudo-second-order model using linear and nonlinear regression analysis. With the clear relationship between increased modulus and composition, this study enabled the fine-tuning of semi-IPN interactions by varying the polymerization temperature.
提出了一种替代合成途径，用于优化合成过程，以通过温度调节找到透明质酸互穿凝胶的溶胀与弹性之间更好的相关性。提出了一种实验设计方法，用于合成聚丙烯酰胺/聚丙烯酸钠盐/透明质酸（PAAm/PSA/HyA）凝胶，通过在不同量（0.05%至0.20%，/）的HyA存在下，使用AAm的自由基交联共聚改性一锅法来添加阴离子线性PSA链。设计了具有可调弹性的半互穿聚合物网络（IPN）结构凝胶，其中共价交联相互作用的程度由-18至45°C的聚合温度控制。根据合成中添加的HyA含量和聚合温度，可以控制溶胀率。添加0.05%（/）的HyA会增加半互穿网络的溶胀，而弹性模量随HyA含量的增加而增加，并随聚合温度的降低而降低。PAAm/PSA/HyA半互穿网络显示出阴离子凝胶典型的pH敏感溶胀，在pH为11.2时溶胀达到最大值。测试了PAAm/PSA/HyA凝胶对废水中甲基紫的去除效果。通过线性和非线性回归分析表明吸附动力学与伪二级模型拟合良好。由于模量增加与组成之间存在明确关系，本研究能够通过改变聚合温度来微调半互穿网络的相互作用。
