Schmidt E B, Møller-Petersen J
Scand J Prim Health Care. 1985 May;3(2):91-4. doi: 10.3109/02813438509013923.
The diagnostic value of typing and quantitation of immunoglobulins were investigated in 88 persons with monoclonal gammopathy diagnosed in general practice. Of the 88 persons, 13 had malignant monoclonal gammopathy (MMG) and 75 monoclonal gammopathy of undetermined significance (MGUS). IgG was the immunoglobulin most often associated with a benign disorder. The higher the concentration of M-component was, the higher too was the frequency of MMG. All 40 persons with normal levels of immunoglobulins had MGUS. Suppression of immunoglobulins other than the M-component was found in 69% with MMG and 20% with MGUS. The combination of an elevated level of monoclonal immunoglobulin and suppression of other immunoglobulins was seen in 69% with MMG, but in only 12% with MGUS. The results from typing and quantitating may serve to indicate whether further investigations are justified in patients not suspected of MMG, but in whom a M-component is found.
对88例在全科医疗中诊断为单克隆丙种球蛋白病的患者进行了免疫球蛋白分型和定量的诊断价值研究。在这88例患者中，13例患有恶性单克隆丙种球蛋白病（MMG），75例为意义未明的单克隆丙种球蛋白病（MGUS）。IgG是最常与良性疾病相关的免疫球蛋白。M成分浓度越高，MMG的发生率也越高。所有40例免疫球蛋白水平正常的患者均患有MGUS。在69%的MMG患者和20%的MGUS患者中发现了除M成分外其他免疫球蛋白的抑制。69%的MMG患者出现单克隆免疫球蛋白水平升高和其他免疫球蛋白抑制的组合，但MGUS患者中仅为12%。分型和定量结果可用于指示在未怀疑患有MMG但发现有M成分的患者中是否有必要进行进一步检查。
